Synthesis, Characterization and Antibacterial Activity of Some New Neocuproine Schiff Bases

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Habibi Juybari Mohammad; PORDELI HAMIDREZA; Mikaeili Saeid

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Journal Paper

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Journal: MEDICAL LABORATORY JOURNAL Year:2019 | Volume:13 | Issue:3 Page(s): 35-39

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Title

Synthesis, Characterization and Antibacterial Activity of Some New Neocuproine Schiff Bases

Author(s)

Habibi Juybari Mohammad | PORDELI HAMIDREZA | Mikaeili Saeid | Issue Writer Certificate

Keywords

Schiff bases

antibacterial effect

Staphylococcus aureus

Escherichia coli

Pseudomonas aeruginosa

Abstract

Background and Objectives: Schiff base ligands are prepared via the condensation reaction of 1, 10-dimethyl– phenantroline aldehyde derivative with some nitrogen donor ligands, such as benzene ring that have different functional groups (-OH,-SH,-OCH3,-CH2OH,-Br) in acetonitrile. Recent studies suggest that Schiff bases might have antibacterial activity. Therefore, we aimed to synthesize new Schiff base complexes and evaluate their antibacterial activity against a number of Gram-positive and Gram-negative bacteria. Methods: Schiff base ligands and their complexes were characterized by mass spectrometry, infrared spectroscopy and nuclear magnetic resonance spectroscopy. The in vitro antibacterial activity of the Schiff base ligands and metal ions against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa was evaluated by determining minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) using the broth dilution method. Results: All synthesized Schiff bases exhibited favorable antibacterial activity against the tested microorganism, but the antibacterial effect of compounds 3OH and 3SH was more significant than that of other compounds. Conclusion: Compound 3EOH has favorable antibacterial activity against the tested bacteria.

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APA: Copy

Habibi Juybari, Mohammad, PORDELI, HAMIDREZA, & Mikaeili, Saeid. (2019). Synthesis, Characterization and Antibacterial Activity of Some New Neocuproine Schiff Bases. MEDICAL LABORATORY JOURNAL, 13(3), 35-39. SID. https://sid.ir/paper/715755/en

Vancouver: Copy

Habibi Juybari Mohammad, PORDELI HAMIDREZA, Mikaeili Saeid. Synthesis, Characterization and Antibacterial Activity of Some New Neocuproine Schiff Bases. MEDICAL LABORATORY JOURNAL[Internet]. 2019;13(3):35-39. Available from: https://sid.ir/paper/715755/en

IEEE: Copy

Mohammad Habibi Juybari, HAMIDREZA PORDELI, and Saeid Mikaeili, “Synthesis, Characterization and Antibacterial Activity of Some New Neocuproine Schiff Bases,” MEDICAL LABORATORY JOURNAL, vol. 13, no. 3, pp. 35–39, 2019, [Online]. Available: https://sid.ir/paper/715755/en

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