Forced Expiratory Flow at 25– 75% as a Marker for Airway Hyper Responsiveness in Adult Patients with Asthma-like Symptoms

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RAJI HANIEH; HADDADZADEH SHOUSHTARI MARYAM; IDANI ESMAEIL; TAVAKOL HESHMATOLLAH; Afrakhteh Sakineh; DASTOORPOOR MARYAM; BORSI SEYED HAMID

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Journal: TANAFFOS Year:2018 | Volume:17 | Issue:2 Page(s): 90-95

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Title

Forced Expiratory Flow at 25– 75% as a Marker for Airway Hyper Responsiveness in Adult Patients with Asthma-like Symptoms

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Keywords

Airway Hyper-Responsiveness

Methacholine Challenge Test

Asthma

FEF25-75

Abstract

Background: The aim of the present study was threefold: to assess the association between baseline FEF25-75 and Airway Hyper-Responsiveness (AHR), to specify whether a decrease in FEF25-75 may reflect severe hyper-responsiveness, and finally to confirm a FEF 25-75 cut-off value. Materials and Methods: In a cross sectional study in Imam Khomeini Hospital, Ahvaz, patients suffering from respiratory symptoms due the 2013 autumn rainfall with normal FEV1 and FEV1/FVC were evaluated by Methacholine Challenge Test. Those with PD20<1000, 10002000 μ g were classified as severe, moderate and mild AHR, respectively. Data were analyzed using Chi-square, Independent t-test, One-way ANOVA and Receiver Operating Characteristic (ROC) curve. Results: Among the 234 patients, mean baseline FEF25-75 was 84. 2± 22. 7% for 54 patients having a negative bronchial provocation test result and 70. 9± 19. 2% for 179 patients with a positive bronchial provocation test result (P < 0. 0001). No change was observed in the median PD20 among patients with a higher baseline FEF25-75. ROC analysis showed that FEF25-75 could potentially be a predictor of AHR, but it could not confirm the cut-off value of FEF25-75 for these patients. Conclusion: When Asthma begins, AHR could be predicted by impaired FEF25-75 with normal FEV1 and FEV1/FVC. However, we could not determine a cut-off value, and no association was found between a greater impairment of FEF25-75 and a more severe AHR.

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APA: Copy

RAJI, HANIEH, HADDADZADEH SHOUSHTARI, MARYAM, IDANI, ESMAEIL, TAVAKOL, HESHMATOLLAH, Afrakhteh, Sakineh, DASTOORPOOR, MARYAM, & BORSI, SEYED HAMID. (2018). Forced Expiratory Flow at 25– 75% as a Marker for Airway Hyper Responsiveness in Adult Patients with Asthma-like Symptoms. TANAFFOS, 17(2), 90-95. SID. https://sid.ir/paper/715771/en

Vancouver: Copy

RAJI HANIEH, HADDADZADEH SHOUSHTARI MARYAM, IDANI ESMAEIL, TAVAKOL HESHMATOLLAH, Afrakhteh Sakineh, DASTOORPOOR MARYAM, BORSI SEYED HAMID. Forced Expiratory Flow at 25– 75% as a Marker for Airway Hyper Responsiveness in Adult Patients with Asthma-like Symptoms. TANAFFOS[Internet]. 2018;17(2):90-95. Available from: https://sid.ir/paper/715771/en

IEEE: Copy

HANIEH RAJI, MARYAM HADDADZADEH SHOUSHTARI, ESMAEIL IDANI, HESHMATOLLAH TAVAKOL, Sakineh Afrakhteh, MARYAM DASTOORPOOR, and SEYED HAMID BORSI, “Forced Expiratory Flow at 25– 75% as a Marker for Airway Hyper Responsiveness in Adult Patients with Asthma-like Symptoms,” TANAFFOS, vol. 17, no. 2, pp. 90–95, 2018, [Online]. Available: https://sid.ir/paper/715771/en

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