HUMAN NEURAL STEM/PROGENITOR CELLS DERIVED FROM EPILEPTIC HUMAN BRAIN IN A SELF-ASSEMBLING PEPTIDE NANOSCAFFOLD IMPROVE TRAUMATIC BRAIN INJURY IN RATS (ORAL PRESENTATION)

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JAHANBAZI JAHAN ABAD ALI; SAHAB NEGAH SAJAD; HOSSEINI RAVANDI HASSAN; GHASEMI SEPIDEH; BORHANI HAGHIGHI MARYAM; STUMMER WALTER; GORJI ALI; KHALEGHI GHADIRI MARYAM

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Journal: Neuroscience Journal of Shefaye Khatam Year:2018 | Volume:6 | Issue:3 (SUPPLEMENT 2) Page(s): 24-24

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Title

HUMAN NEURAL STEM/PROGENITOR CELLS DERIVED FROM EPILEPTIC HUMAN BRAIN IN A SELF-ASSEMBLING PEPTIDE NANOSCAFFOLD IMPROVE TRAUMATIC BRAIN INJURY IN RATS (ORAL PRESENTATION)

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Keywords

TISSUE ENGINEERING

HUMAN NEURAL STEM CELLS

TRAUMATIC BRAIN INJURY

EPILEPSY

Abstract

Traumatic brain injury (TBI) is a disruption in the brain functions as a result of an external force. To date, the main problem is that no direct effective therapies exist for brain injury treatment. It is thought that stem Cell therapy may provide a promising treatment for TBI. The use of human-derived stem/progenitor cells seeded in three- dimensional (3D) micro-environments have shown as a promising novel method for cell replacement therapy in TBI. The project aims here were to investigate the effects of human neural stem/progenitor cells (hNS/PCs) derived from the resected mesial temporal lobe brain tissues and human adipose-derived stromal/stem cells (hADSCs) cultured in PuraMatrix hydrogel (PM) on brain function in animal models of TBI. By comparing the results of doubling time characteristics of hNS/PCs and hADSCs, revealed that hNS/PCs doubling time was significantly longer than hADSC. Transplantation of hNS/PCs and hADSCs seeded in PM after TBI does seem to improved functional recovery, decreased lesion volume, inhibited neuroinflammation, and reduced the reactive gliosis at the injury site in rats. The data suggest the hNS/PCs derived from epileptic human brain seeded in PM scaffold can be used for the potential cell therapy for neurological disorders, such as TBI.

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APA: Copy

JAHANBAZI JAHAN ABAD, ALI, SAHAB NEGAH, SAJAD, HOSSEINI RAVANDI, HASSAN, GHASEMI, SEPIDEH, BORHANI HAGHIGHI, MARYAM, STUMMER, WALTER, GORJI, ALI, & KHALEGHI GHADIRI, MARYAM. (2018). HUMAN NEURAL STEM/PROGENITOR CELLS DERIVED FROM EPILEPTIC HUMAN BRAIN IN A SELF-ASSEMBLING PEPTIDE NANOSCAFFOLD IMPROVE TRAUMATIC BRAIN INJURY IN RATS (ORAL PRESENTATION). NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 6(3 (SUPPLEMENT 2)), 24-24. SID. https://sid.ir/paper/716601/en

Vancouver: Copy

JAHANBAZI JAHAN ABAD ALI, SAHAB NEGAH SAJAD, HOSSEINI RAVANDI HASSAN, GHASEMI SEPIDEH, BORHANI HAGHIGHI MARYAM, STUMMER WALTER, GORJI ALI, KHALEGHI GHADIRI MARYAM. HUMAN NEURAL STEM/PROGENITOR CELLS DERIVED FROM EPILEPTIC HUMAN BRAIN IN A SELF-ASSEMBLING PEPTIDE NANOSCAFFOLD IMPROVE TRAUMATIC BRAIN INJURY IN RATS (ORAL PRESENTATION). NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2018;6(3 (SUPPLEMENT 2)):24-24. Available from: https://sid.ir/paper/716601/en

IEEE: Copy

ALI JAHANBAZI JAHAN ABAD, SAJAD SAHAB NEGAH, HASSAN HOSSEINI RAVANDI, SEPIDEH GHASEMI, MARYAM BORHANI HAGHIGHI, WALTER STUMMER, ALI GORJI, and MARYAM KHALEGHI GHADIRI, “HUMAN NEURAL STEM/PROGENITOR CELLS DERIVED FROM EPILEPTIC HUMAN BRAIN IN A SELF-ASSEMBLING PEPTIDE NANOSCAFFOLD IMPROVE TRAUMATIC BRAIN INJURY IN RATS (ORAL PRESENTATION),” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 6, no. 3 (SUPPLEMENT 2), pp. 24–24, 2018, [Online]. Available: https://sid.ir/paper/716601/en

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