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Information Journal Paper

Title

Immunohistochemical and Electron Microscopic Study of the Inhibitory Effects of Olive Oil Polyphenol on Dexamethasone-Induced Apoptosis

Pages

  45-52

Abstract

 Background: There is accumulating evidence that a polyphenol present in olive oil, Oleuropein, has antioxidant, anti-inflammatory and anti-apoptotic effects. This study aimed at determining the anti-apoptotic effect of Oleuropein (Ole) on Dexamethasone-induced Apoptosis of mouse Thymocytes. Method: Mice were randomly divided to four groups as follow: Dexamethasone (Dex)-treated group (20 mg/kg; single dose), Ole-treated group (20 mg/kg per day), Dex plus Ole-treated group, and vehicle group. Sections of thymus were taken 16 hours after Dexamethasone injection and studied for histopathological and immunohistochemistry assessment. Result: Further characteristics of degeneration in Thymocytes were observed in the Dex group compared with the Dex plus Ole group. Compared with the Dex group (10. 94± 3. 35), positive staining for Bax in Thymocytes decreased in Dex plus Ole group (2. 64± 1. 26), but remained higher than the Ole (0. 65± 0. 30) and vehicle (0. 67± 0. 29) groups. Compared with the Dex group (2. 94± 0. 42), positive staining for Bcl-2 in Thymocytes increased in Dex plus Ole group (12. 24± 1. 84) yet was lower than the Ole (14. 94± 1. 54) and vehicle (18. 93± 3. 54) groups. Conclusion: Our results suggest that Dexamethasone-induced Apoptosis is subsided by Oleuropein.

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    APA: Copy

    KHALATBARY, ALI REZA, MOHAMMADNEGAD, BEHROOZ, GOUDARZI, GHAZALEH, & Fazlollahpour Balef, Ali. (2017). Immunohistochemical and Electron Microscopic Study of the Inhibitory Effects of Olive Oil Polyphenol on Dexamethasone-Induced Apoptosis. IRANIAN JOURNAL OF PATHOLOGY (IJP), 12(1), 45-52. SID. https://sid.ir/paper/716838/en

    Vancouver: Copy

    KHALATBARY ALI REZA, MOHAMMADNEGAD BEHROOZ, GOUDARZI GHAZALEH, Fazlollahpour Balef Ali. Immunohistochemical and Electron Microscopic Study of the Inhibitory Effects of Olive Oil Polyphenol on Dexamethasone-Induced Apoptosis. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2017;12(1):45-52. Available from: https://sid.ir/paper/716838/en

    IEEE: Copy

    ALI REZA KHALATBARY, BEHROOZ MOHAMMADNEGAD, GHAZALEH GOUDARZI, and Ali Fazlollahpour Balef, “Immunohistochemical and Electron Microscopic Study of the Inhibitory Effects of Olive Oil Polyphenol on Dexamethasone-Induced Apoptosis,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 12, no. 1, pp. 45–52, 2017, [Online]. Available: https://sid.ir/paper/716838/en

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