Alpha-Synuclein Expression in Acute Erythroleukaemia, Acute Megakaryoblastic Leukemia, and Normal Counterparts in Bone Marrow

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KOSARI FARID; Akbarzadeh Hosseini Sanam; SAFFAR HIVA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PATHOLOGY (IJP) Year:2017 | Volume:12 | Issue:1 Page(s): 74-78

Download Full-Text

View:

183

Download:

134

Cites:

Information Journal Paper

Title

Alpha-Synuclein Expression in Acute Erythroleukaemia, Acute Megakaryoblastic Leukemia, and Normal Counterparts in Bone Marrow

Author(s)

KOSARI FARID | Akbarzadeh Hosseini Sanam | SAFFAR HIVA | Issue Writer Certificate

Keywords

Acute Myeloblastic Leukemia

AML-M6

AML-M7

α-Synuclein

Abstract

Background: Alpha-synuclein is a member of synuclein family of proteins with unidentified function localized in the cytoplasm, mitochondria of neurons, and presynaptic nerve endings. Although it is found in the Lewy bodies in synucleinopathies and in Alzheimer’ s disease, the protein could also be considered as a novel marker in diagnosis of diseases related to the hematopoietic system. Methods: The current study evaluated alpha-synuclein expression in bone marrow sections obtained from 9 patients with Acute Myeloblastic Leukemia (AML)-M6, 2 patients with AML-M7, and 56 patients with other forms of AML by immunohistochemical (IHC) analysis Results: Seven out of 9 cases with erythroleukemia (66. 7%) and 1 of the 2 cases with M7 (50%) were positive. In contrast; the blasts in 2 out of 56 AML cases with non-M6/M7 (3. 6%) showed positive staining. Accordingly, alpha-synuclein was positive in normal erythroid precursors and megakaryocytes (if existing) in these cases; while, it was negative in lymphoid and myeloid precursors. Conclusion: Alpha-synuclein expression in non-neoplastic and neoplastic erythroid cells and megakaryocytes could be used as a complementary and useful marker for distinction between AML-M6/M7 and other types of AML.

Cites

No record.

References

No record.

Cite

APA: Copy

KOSARI, FARID, Akbarzadeh Hosseini, Sanam, & SAFFAR, HIVA. (2017). Alpha-Synuclein Expression in Acute Erythroleukaemia, Acute Megakaryoblastic Leukemia, and Normal Counterparts in Bone Marrow. IRANIAN JOURNAL OF PATHOLOGY (IJP), 12(1), 74-78. SID. https://sid.ir/paper/716984/en

Vancouver: Copy

KOSARI FARID, Akbarzadeh Hosseini Sanam, SAFFAR HIVA. Alpha-Synuclein Expression in Acute Erythroleukaemia, Acute Megakaryoblastic Leukemia, and Normal Counterparts in Bone Marrow. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2017;12(1):74-78. Available from: https://sid.ir/paper/716984/en

IEEE: Copy

FARID KOSARI, Sanam Akbarzadeh Hosseini, and HIVA SAFFAR, “Alpha-Synuclein Expression in Acute Erythroleukaemia, Acute Megakaryoblastic Leukemia, and Normal Counterparts in Bone Marrow,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 12, no. 1, pp. 74–78, 2017, [Online]. Available: https://sid.ir/paper/716984/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops