Molecular changes in obese and depressive patients are similar to neurodegenerative disorders

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HABIBI LALEH; TAFAKHORI ABBAS; Hadiani Rasoul; Maserat Mashhadi Maryam; Kafrash Zeinab; Torabi Shahla; Azhdarzadeh Mohammad; AKRAMI SEYED MOHAMMAD; MAHMOUDI MORTEZA; DINARVAND RASOUL

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Journal: Current Journal of Neurology Year:2017 | Volume:16 | Issue:4 Page(s): 192-200

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Title

Molecular changes in obese and depressive patients are similar to neurodegenerative disorders

Author(s)

Keywords

Obesity

Depression

Neurodegeneration

Forkhead Box Protein

Heavy Metals

Lifestyle

Abstract

Background: Neurodegenerative disorders (NDs) are categorized as multifactorial conditions with different molecular and environmental causes. Disturbance of important signaling pathways, such as energy metabolism and inflammation induced by environmental agents, is involved in the pathophysiology of NDs. It has been proposed that changes in the Lifestyle and nutrition (metabolism) during mid-life could trigger and accumulate cellular and molecular damages resulting in NDs during aging. Methods: In order to test the hypothesis, we investigated the expression level of two energy metabolism-related [forkhead box O1 (FOXO1) and forkhead box O3 (FOXO3A)] and two pro-inflammatory cytokines [interleukin 1β (IL-1β ) and IL-6] genes, using quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR). Furthermore, changes in the ionic concentration of three essential Heavy Metals [iron (Fe), copper (Cu), and zinc (Zn)] by atomic absorption spectroscopy in patients with NDs, Depression, Obesity, and diabetes type II, were evaluated and compared with the results of normal individuals. Results: More than half of the participants in Obesity, Depression, and ND groups had significant up-regulation of FOXO1 and FOXO3A, down-regulation of IL-1β and IL-6, and higher levels of Fe and Cu in their blood. This pattern of gene expression was not repeated in diabetic patients. Conclusion: It could be concluded that individuals affected with different levels of Obesity and Depression have increased risk of developing NDs later in life, probably through changes in energy metabolism, inflammatory pathways, and ionic concentrations.

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APA: Copy

HABIBI, LALEH, TAFAKHORI, ABBAS, Hadiani, Rasoul, Maserat Mashhadi, Maryam, Kafrash, Zeinab, Torabi, Shahla, Azhdarzadeh, Mohammad, AKRAMI, SEYED MOHAMMAD, MAHMOUDI, MORTEZA, & DINARVAND, RASOUL. (2017). Molecular changes in obese and depressive patients are similar to neurodegenerative disorders. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 16(4), 192-200. SID. https://sid.ir/paper/717527/en

Vancouver: Copy

HABIBI LALEH, TAFAKHORI ABBAS, Hadiani Rasoul, Maserat Mashhadi Maryam, Kafrash Zeinab, Torabi Shahla, Azhdarzadeh Mohammad, AKRAMI SEYED MOHAMMAD, MAHMOUDI MORTEZA, DINARVAND RASOUL. Molecular changes in obese and depressive patients are similar to neurodegenerative disorders. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2017;16(4):192-200. Available from: https://sid.ir/paper/717527/en

IEEE: Copy

LALEH HABIBI, ABBAS TAFAKHORI, Rasoul Hadiani, Maryam Maserat Mashhadi, Zeinab Kafrash, Shahla Torabi, Mohammad Azhdarzadeh, SEYED MOHAMMAD AKRAMI, MORTEZA MAHMOUDI, and RASOUL DINARVAND, “Molecular changes in obese and depressive patients are similar to neurodegenerative disorders,” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 16, no. 4, pp. 192–200, 2017, [Online]. Available: https://sid.ir/paper/717527/en

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