Effects of pyridoxine supplementation on severity, frequency and duration of migraine attacks in migraine patients with aura: A double-blind randomized clinical trial study in Iran

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Sadeghi Omid; NASIRI MORTEZA; MAGHSOUDI ZAHRA; Pahlavani Naseh; REZAIE MASOUD; ASKARI GHOLAMREZA

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Journal: Current Journal of Neurology Year:2015 | Volume:14 | Issue:2 Page(s): 74-80

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Title

Effects of pyridoxine supplementation on severity, frequency and duration of migraine attacks in migraine patients with aura: A double-blind randomized clinical trial study in Iran

Author(s)

Keywords

Migraine with Aura

Pyridoxine

Headache

Iran

Abstract

Background: Migraine is a chronic disease that affects nearly 6% of men and 18% of women worldwide. There are various drugs, which can successfully decrease migraine symptoms and frequency of migraine attacks, but these drugs usually are expensive. Hence, this study aimed to assess the effects of Pyridoxine supplementation on severity, frequency and duration of migraine attacks as well as Headache diary results (HDR). Methods: This double-blind randomized clinical trial study was conducted on 66 patients with Migraine with Aura (MA) in Khorshid and Emam Mosa Sadr clinics of Isfahan University of Medical Sciences, Iran, in 2013. Patients were randomly allocated to receive either Pyridoxine supplements (80 mg Pyridoxine per day) or placebo. Severity, frequency and duration of migraine attacks and HDR were measured at baseline and at the end of the study. Results: Mean age of patients was 34. 24 ± 9. 44 years old. Pyridoxine supplementation led to a significant decrease in Headache severity (− 2. 20 ± 1. 70 compared with − 1 ± 1. 50; P = 0. 007), attacks duration (− 8. 30 ± 12. 60 compared with − 1. 70 ± 9. 60; P = 0. 030) and HDR (− 89. 70 ± 134. 60 compared with − 6. 10 ± 155. 50; P = 0. 040) compared with placebo, but was not effective on the frequency of migraine attacks (− 2. 30 ± 4 compared with − 1. 20 ± 7. 80; P = 0. 510). Conclusion: Pyridoxine supplementation in patients with MA was effective on Headache severity, attacks duration and HDR, but did not affect the frequency of migraine attacks.

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APA: Copy

Sadeghi, Omid, NASIRI, MORTEZA, MAGHSOUDI, ZAHRA, Pahlavani, Naseh, REZAIE, MASOUD, & ASKARI, GHOLAMREZA. (2015). Effects of pyridoxine supplementation on severity, frequency and duration of migraine attacks in migraine patients with aura: A double-blind randomized clinical trial study in Iran. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 14(2), 74-80. SID. https://sid.ir/paper/717529/en

Vancouver: Copy

Sadeghi Omid, NASIRI MORTEZA, MAGHSOUDI ZAHRA, Pahlavani Naseh, REZAIE MASOUD, ASKARI GHOLAMREZA. Effects of pyridoxine supplementation on severity, frequency and duration of migraine attacks in migraine patients with aura: A double-blind randomized clinical trial study in Iran. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2015;14(2):74-80. Available from: https://sid.ir/paper/717529/en

IEEE: Copy

Omid Sadeghi, MORTEZA NASIRI, ZAHRA MAGHSOUDI, Naseh Pahlavani, MASOUD REZAIE, and GHOLAMREZA ASKARI, “Effects of pyridoxine supplementation on severity, frequency and duration of migraine attacks in migraine patients with aura: A double-blind randomized clinical trial study in Iran,” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 14, no. 2, pp. 74–80, 2015, [Online]. Available: https://sid.ir/paper/717529/en

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