Preliminary Findings of Platelet-Rich Plasma-Induced Ameliorative Effect on Polycystic Ovarian Syndrome

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Seyyed Anvari Samira; Dehgan Gholamreza; RAZI MAZDAK

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Journal Paper

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Journal: Cell Journal (Yakhteh) Year:2019 | Volume:21 | Issue:3 Page(s): 243-252

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Title

Preliminary Findings of Platelet-Rich Plasma-Induced Ameliorative Effect on Polycystic Ovarian Syndrome

Author(s)

Seyyed Anvari Samira | Dehgan Gholamreza | RAZI MAZDAK | Issue Writer Certificate

Keywords

Folliculogenesis

Oxidative Stress

Platelet-Rich Plasma

Polycystic Ovarian Syndrome

Rat

Abstract

Objective: Polycystic Ovarian Syndrome (PCOS) is characterized by hormonal imbalance, Oxidative Stress and chronic anovulation. The present study was designed to assess amelioRative effect of auto-locating Platelet-Rich Plasma (PRP), as a novel method, for inhibiting PCOS-induced pathogenesis in experimentally-induced hyperandrogenic PCOS. Materials and Methods: In this experimental study, 30 immature (21 days old) female Rats were assigned into five groups, including control (sampled after 30 days with no treatment), 15 and 30 days PCOS-sole-induced as well as 15 and 30 days PRP auto-located PCOS-induced groups. Serum levels of estrogen, progesterone, androstenedione, testosterone, follicle stimulating hormone (FSH), luteinizing hormone (LH), ovarian total antioxidant capacity (TAC), malondialdehyde (MDA), glutathione peroxidase (GSH-px) and superoxide dismutase (SOD) were evaluated. Expression of estrogen receptor α (Erα ), β (Erβ ) and c-Myc were assessed. Finally, the numbers of intact follicles per ovary and mRNA damage Ratio were analyzed. Results: PRP groups significantly (P<0. 05) decreased serum levels of FSH, LH, testosterone and androstenedione and remarkably (P<0. 05) increased estrogen and progesterone syntheses versus PCOS-sole groups. The PRP auto-located animals exhibited increased TAC, GSH-px and SOD levels, while they showed diminished MDA content (P<0. 05) versus PCOS-sole groups. The PRP auto-located groups exhibited an elevated expression of Erα and Erβ versus PCOS-sole groups. Moreover, PRP groups significantly (P<0. 05) decreased c-Myc expression and mRNA damage compared to PCOS-sole groups, and remarkably improved follicular growth. Conclusion: PRP is able to regulate hormonal interaction, improve the ovarian antioxidant potential as well as Folliculogenesis and its auto-location could be considered as a novel method to prevent/amelioRate PCOS-induced pathogenesis.

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References

ANTIOXIDANTS AND MANAGEMENT OF POLYCYSTIC OVARY SYNDROME IN IRAN: A SYSTEMATIC REVIEW OF CLINICAL TRIALS

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APA: Copy

Seyyed Anvari, Samira, Dehgan, Gholamreza, & RAZI, MAZDAK. (2019). Preliminary Findings of Platelet-Rich Plasma-Induced Ameliorative Effect on Polycystic Ovarian Syndrome. CELL JOURNAL (YAKHTEH), 21(3), 243-252. SID. https://sid.ir/paper/718501/en

Vancouver: Copy

Seyyed Anvari Samira, Dehgan Gholamreza, RAZI MAZDAK. Preliminary Findings of Platelet-Rich Plasma-Induced Ameliorative Effect on Polycystic Ovarian Syndrome. CELL JOURNAL (YAKHTEH)[Internet]. 2019;21(3):243-252. Available from: https://sid.ir/paper/718501/en

IEEE: Copy

Samira Seyyed Anvari, Gholamreza Dehgan, and MAZDAK RAZI, “Preliminary Findings of Platelet-Rich Plasma-Induced Ameliorative Effect on Polycystic Ovarian Syndrome,” CELL JOURNAL (YAKHTEH), vol. 21, no. 3, pp. 243–252, 2019, [Online]. Available: https://sid.ir/paper/718501/en

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