Comparison of Hypoallergenic Diet vs. Ranitidine in Treatment of Gastroesophageal Reflux Disease of Infants: A Randomized Clinical Trial

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FAMOURI FATEMEH; Zibanejad Nazanin; KABIRI PAYAM; KELISHADI ROYA

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Journal: Iranian Journal of Pediatrics Year:2017 | Volume:27 | Issue:4 Page(s): 0-0

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Title

Comparison of Hypoallergenic Diet vs. Ranitidine in Treatment of Gastroesophageal Reflux Disease of Infants: A Randomized Clinical Trial

Author(s)

FAMOURI FATEMEH | Zibanejad Nazanin | KABIRI PAYAM | KELISHADI ROYA | Issue Writer Certificate

Keywords

Gastroesophageal Reflux Disease

Anitidine

Food Allergy

Abstract

Background: Gastroesophageal Reflux Disease (GERD) is defined as “ troublesome symptoms or complications of GER” , and is a multifactorial disorder. This study aimed to compare the treatment outcomes of hypoallergenic diet vs. rAnitidine on symptoms of Gastroesophageal Reflux Disease (GERD) in infants. Methods: In this randomized clinical trial, 50 patients aged less than 1 year, who were suspected to have GERD on the basis of IGERQ-R, were enrolled. They were randomly allocated to two groups of equal number, one group received rAnitidine and the other hypoallergenic diet for 2 weeks. The frequency of GERD symptoms, including irritability, vomiting, anorexia, respiratory symptoms and arching, were compared between the two groups before and after the trial. Results: After a two-week trial, the frequency of vomiting and respiratory symptoms decreased significantly in both groups (P < 0. 05). The frequency of vomiting decreased in 19 (76%) and 19 (76%) of infants in rAnitidine and hypoallergenic diet groups, respectively (P = 0. 05 between groups). Moreover, the respiratory symptoms improved significantly in both groups (P < 0. 05). The frequency of irritability did not decrease significantly in any of the groups (P = 0. 18). Conclusions: The current findings suggest that the hypoallergenic diet might have significant effect on GERD symptoms; these effects are comparable with those of rAnitidine. Considering the possibility of cow’ s milk protein allergy in this group of patients, werecommendthat the treatment of GERDin pediatric population be initiated with hypoallergenic diet and in case of not achieving significant effect, pharmacological treatment be added and applied as a combination therapy.

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APA: Copy

FAMOURI, FATEMEH, Zibanejad, Nazanin, KABIRI, PAYAM, & KELISHADI, ROYA. (2017). Comparison of Hypoallergenic Diet vs. Ranitidine in Treatment of Gastroesophageal Reflux Disease of Infants: A Randomized Clinical Trial. IRANIAN JOURNAL OF PEDIATRICS, 27(4), 0-0. SID. https://sid.ir/paper/718574/en

Vancouver: Copy

FAMOURI FATEMEH, Zibanejad Nazanin, KABIRI PAYAM, KELISHADI ROYA. Comparison of Hypoallergenic Diet vs. Ranitidine in Treatment of Gastroesophageal Reflux Disease of Infants: A Randomized Clinical Trial. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2017;27(4):0-0. Available from: https://sid.ir/paper/718574/en

IEEE: Copy

FATEMEH FAMOURI, Nazanin Zibanejad, PAYAM KABIRI, and ROYA KELISHADI, “Comparison of Hypoallergenic Diet vs. Ranitidine in Treatment of Gastroesophageal Reflux Disease of Infants: A Randomized Clinical Trial,” IRANIAN JOURNAL OF PEDIATRICS, vol. 27, no. 4, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/718574/en

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