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Information Journal Paper

Title

Fermented Garlic Extract Increases Oxygen Consumption and UCP-1 mRNA Expression in Human Adipose-Derived Stem Cells

Pages

  357-362

Abstract

 Fermented Garlic, often called black Garlic, is a traditional food ingredient used in Asian cuisine and possesses various health benefits including anti-obesity activity. The anti-obesity effects of fermented Garlic might, in part, might be mediated through direct actions of its components on adipocytes. To test this hypothesis, we examined whether fermented Garlic extract might stimulate the metabolic activity of human Adipose-Derived Stem Cells (ADSCs) in culture. Cell viability measured by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium (MTT) assay exhibited a complex doseresponse relationship. The lowest concentration (0. 4 mg/ml) reduced cell viability (P<0. 05 compared to no extract, Bonferroni’ s multiple comparison), whereas higher concentrations (0. 8 and 1. 0 mg/ml) resulted in higher cell viability (P<0. 05 as compared to 0. 4 mg/ml). However, the extract at concentrations >2 mg/ml markedly decreased cell viability. Higher cell viability observed following treatment with 0. 8~1. 0 mg/ml might be associated with raised Oxygen Consumption. Fluorescent dye-based measurement revealed that the Garlic extract at 1. 0 mg/ml significantly increased Oxygen Consumption. We also detected a significant increase in mRNA expression levels of uncoupling protein-1 (UCP-1). These findings suggest that fermented Garlic stimulates the basal metabolic activity of human ADSCs.

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    Cite

    APA: Copy

    Park, Eulsoon, Baek, Seung Hwa, Bang, Keuk Su, Kim, Na Hyung, & Takimoto, Koichi. (2019). Fermented Garlic Extract Increases Oxygen Consumption and UCP-1 mRNA Expression in Human Adipose-Derived Stem Cells. CELL JOURNAL (YAKHTEH), 21(3), 357-362. SID. https://sid.ir/paper/718658/en

    Vancouver: Copy

    Park Eulsoon, Baek Seung Hwa, Bang Keuk Su, Kim Na Hyung, Takimoto Koichi. Fermented Garlic Extract Increases Oxygen Consumption and UCP-1 mRNA Expression in Human Adipose-Derived Stem Cells. CELL JOURNAL (YAKHTEH)[Internet]. 2019;21(3):357-362. Available from: https://sid.ir/paper/718658/en

    IEEE: Copy

    Eulsoon Park, Seung Hwa Baek, Keuk Su Bang, Na Hyung Kim, and Koichi Takimoto, “Fermented Garlic Extract Increases Oxygen Consumption and UCP-1 mRNA Expression in Human Adipose-Derived Stem Cells,” CELL JOURNAL (YAKHTEH), vol. 21, no. 3, pp. 357–362, 2019, [Online]. Available: https://sid.ir/paper/718658/en

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