Endothelial Dysfunction in Children with Steroid-Resistant Nephrotic Syndrome

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KARI JAMEELA ABDULAZIZ; Quinlan Catherine; Deanfield John; Shroff Rukshana; Tullus Kjell

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Journal Paper

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Journal: Iranian Journal of Pediatrics Year:2017 | Volume:27 | Issue:4 Page(s): 0-0

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Title

Endothelial Dysfunction in Children with Steroid-Resistant Nephrotic Syndrome

Author(s)

Keywords

Steroid-Resistant Nephrotic Syndrome

SRNS

cIMT

Children

Abstract

Background: Steroid-Resistant Nephrotic Syndrome (SRNS) is associated with early atherosclerosis because of comorbidities including persistent hyperlipidemia and hypertension. The aim of this study was to determine the incidence of abnormal carotid intima-media thickening (cIMT) as an early sign of atherosclerosis in a small group of Children with SRNS. Methods: A total of 8 Children with SRNS (mean age, 10. 8 4. 2 years at recruitment andmeandisease duration, 40. 9 20. 7 months) were studied; all Children were normotensive. B-mode ultrasound was used to measure cIMT, and the results were compared with healthy controls. Results: Children with SRNS had significantly thicker cIMT (0. 44 0. 04 mm), compared to the controls (0. 37 0. 59mm)(P< 0. 01). A high level of total cholesterol (5. 4 2. 0 mmol/L; normal < 5. 2 mmol/L) was reported in these Children, while normal levels of lowdensity lipoprotein, very-low-density lipoprotein, triglyceride, and high-density lipoprotein were found. Also, the mean creatinine level was 45. 1 15. 0 mol/L, and the mean urea level was 4. 2 1. 8 mmol/L. Conclusions: Children with SRNS had an abnormal vascular phenotype with a thicker cIMT, compared to the controls and showed evidence of hypercholesterolemia.

Cites

Nephrotic Syndrome in Children with This Condition (Letter to Editor)

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APA: Copy

KARI, JAMEELA ABDULAZIZ, Quinlan, Catherine, Deanfield, John, Shroff, Rukshana, & Tullus, Kjell. (2017). Endothelial Dysfunction in Children with Steroid-Resistant Nephrotic Syndrome. IRANIAN JOURNAL OF PEDIATRICS, 27(4), 0-0. SID. https://sid.ir/paper/719928/en

Vancouver: Copy

KARI JAMEELA ABDULAZIZ, Quinlan Catherine, Deanfield John, Shroff Rukshana, Tullus Kjell. Endothelial Dysfunction in Children with Steroid-Resistant Nephrotic Syndrome. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2017;27(4):0-0. Available from: https://sid.ir/paper/719928/en

IEEE: Copy

JAMEELA ABDULAZIZ KARI, Catherine Quinlan, John Deanfield, Rukshana Shroff, and Kjell Tullus, “Endothelial Dysfunction in Children with Steroid-Resistant Nephrotic Syndrome,” IRANIAN JOURNAL OF PEDIATRICS, vol. 27, no. 4, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/719928/en

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