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Information Journal Paper

Title

Cinnamaldehyde and eugenol change the expression folds of AKT1 and DKC1 genes and decrease the telomere length of human adipose-derived stem cells (hASCs): An experimental and in silico study

Pages

  316-326

Abstract

 To investigate the effect of Cinnamaldehyde and Eugenol on the Telomere-dependent senescence of Stem cells. In addition, to search the probable targets of mentioned phytochemicals between human Telomere interacting proteins (TIPs) using in silico studies. Materials and Methods: Human adipose derived Stem cells (hASCs) were studied under treatments with 2. 5 μ M/ml Cinnamaldehyde, 0. 1 μ g/ml Eugenol, 0. 01% DMSO or any additive. The expression of TERT, AKT1 and DKC1 genes and the Telomere length were assessed over 48-hr treatment. In addition, docking study was conducted to show probable ways through which phytochemicals interact with TIPs. Results: Treated and untreated hASCs had undetectable TERT expression, but they had different AKT1 and DKC1 expression levels (CI=0. 95; P<0. 05). The Telomere lengths were reduced in phytochemicals treated with hASCs when compared with the untreated cells (P<0. 05). Docking results showed that the TIPs might be the proper targets for Cinnamaldehyde and Eugenol. Data mining showed there are many targets for Cinnamaldehyde and Eugenol in the intracellular environment. Conclusion: The general effect of Cinnamaldehyde and Eugenol is their induction of stem cell senescence. Therefore, they could be applicable as chemo-preventive or antineoplastic agents.

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    APA: Copy

    ABSALAN, ABDORRAHIM, MESBAH NAMIN, SEYED ALIREZA, TIRAIHI, TAKI, & TAHERI, TAHER. (2017). Cinnamaldehyde and eugenol change the expression folds of AKT1 and DKC1 genes and decrease the telomere length of human adipose-derived stem cells (hASCs): An experimental and in silico study. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(3), 316-326. SID. https://sid.ir/paper/720399/en

    Vancouver: Copy

    ABSALAN ABDORRAHIM, MESBAH NAMIN SEYED ALIREZA, TIRAIHI TAKI, TAHERI TAHER. Cinnamaldehyde and eugenol change the expression folds of AKT1 and DKC1 genes and decrease the telomere length of human adipose-derived stem cells (hASCs): An experimental and in silico study. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(3):316-326. Available from: https://sid.ir/paper/720399/en

    IEEE: Copy

    ABDORRAHIM ABSALAN, SEYED ALIREZA MESBAH NAMIN, TAKI TIRAIHI, and TAHER TAHERI, “Cinnamaldehyde and eugenol change the expression folds of AKT1 and DKC1 genes and decrease the telomere length of human adipose-derived stem cells (hASCs): An experimental and in silico study,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 3, pp. 316–326, 2017, [Online]. Available: https://sid.ir/paper/720399/en

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