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Information Journal Paper

Title

Up-regulation of miR-21 decreases chemotherapeutic effect of dendrosomal curcumin in breast cancer cells

Pages

  350-359

Abstract

 Despite the good results of anticancer activities by Curcumin, there are some hurdles that limit the use of Curcumin as an anticancer agent. Many methods were examined to overcome this defect like the use of the dendrosomal Curcumin (DNC). There is increasing evidence that miRNAs play important roles in biological processes. In this study, we focus on the roles of MicroRNA-21 in the anti-cancer effects of DNC in Breast cancer. Materials and Methods: Also, we have used different methods such as MTT, apoptosis, Cell cycle analysis, transwell migration assay and RT-PCR to find out more. Results: We observed that miR-21 decreased apoptotic cells in both cells (from 6. 35% to 0. 34 % and from 7. 72% to 1. 32% orderly) and DNC increased it. As well as, our findings indicated that cell migration capacity was increased by miR-21 over expression and was decreased by DNC. The combination of miR-21 vector transfection and DNC treatment showed lower percentage of apoptotic cells or a higher level of penetration through the membrane compared with DNC treatment alone. Furthermore, DNC induced a marked increase in the number of cells in sub G1/G1 phase and a decrease in G2/M phase of the Cell cycle in both; but, we observed reverse results compared it, after transfection with miR-21 vector. Conclusion: We observed that miR-21 suppress many aspects of anti-cancer effects of DNC in Breast cancer cells, it seems that co-treatment with DNC and mir-21 down-regulation may provide a clinically useful tool for drug-resistance Breast cancer cells.

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    APA: Copy

    Dehghan Esmatabadi, Mohammad Javad, FARHANGI, BAHARAK, MONTAZERI, MARYAM, Monfared, Hamideh, Nakhaei Sistani, Roohollah, & SADEGHIZADEH, MAJID. (2017). Up-regulation of miR-21 decreases chemotherapeutic effect of dendrosomal curcumin in breast cancer cells. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(4), 350-359. SID. https://sid.ir/paper/720400/en

    Vancouver: Copy

    Dehghan Esmatabadi Mohammad Javad, FARHANGI BAHARAK, MONTAZERI MARYAM, Monfared Hamideh, Nakhaei Sistani Roohollah, SADEGHIZADEH MAJID. Up-regulation of miR-21 decreases chemotherapeutic effect of dendrosomal curcumin in breast cancer cells. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(4):350-359. Available from: https://sid.ir/paper/720400/en

    IEEE: Copy

    Mohammad Javad Dehghan Esmatabadi, BAHARAK FARHANGI, MARYAM MONTAZERI, Hamideh Monfared, Roohollah Nakhaei Sistani, and MAJID SADEGHIZADEH, “Up-regulation of miR-21 decreases chemotherapeutic effect of dendrosomal curcumin in breast cancer cells,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 4, pp. 350–359, 2017, [Online]. Available: https://sid.ir/paper/720400/en

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