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Information Journal Paper

Title

EFFICACY OF INTRAUTERINE INJECTION OF GRANULOCYTE COLONY STIMULATING FACTOR (G-CSF) ON TREATMENT OF UNEXPLAINED RECURRENT MISCARRIAGE: A PILOT RCT STUDY

Pages

  379-385

Abstract

 Background: Endometrium undergoes several changes in structure and cellular composition during pregnancy. GRANULOCYTE COLONY-STIMULATING FACTOR(GCS-F) is an important cytokine with critical role in embryo implantation and pregnancy. The aim of the present study was to evaluate the impact of INTRAUTERINE INJECTION of G-CSF in patients who suffer from unexplained RECURRENT MISCARRIAGE (RM).Methods: In the present randomized clinical trial, a total of 68 patients were randomly allocated into two study groups including intrauterine G-CSF (n=23, 300mg) injection and control group (n=27, no G-CSF injection). Eighteen out of 68 patients were excluded from the final analysis due to different reasons. All patients were in Ovulation Induction (I/O) cycle. In G-CSF group, INTRAUTERINE INJECTION of G-CSF was done twice in the cycle. All enrolled patients were under 40 years old and had at least two unexplained pregnancy losses. Pregnancy was evaluated by titer of bhCG, presence of gestational sac (implantation) and fetal heart rate (clinical pregnancy) was assessed by vaginal ultrasonography. Student’s T test and Mann-Whitney U were used for analysis. The p≤0.05 was determined as statistically significant.Results: No significant differences were observed between the two study groups when the rates of chemical pregnancy (26.1%vs.29.6%, p=0.781), implantation (26.1%vs.22.2%, p=0.750), clinical pregnancy (17.4% vs.11.1%, p=0.689) and abortion (33%vs.37.5%, p=0.296) were compared.Conclusion: In our study, no significant difference was observed between the two study groups when the rates of chemical pregnancy, implantation, clinical pregnancy and abortion were compared.

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    APA: Copy

    ZAFARDOUST, SIMIN, AKHONDI, MOHAMMAD MEHDI, SADEGHI, MOHAMMAD REZA, MOHAMMADZADEH, AFSANEH, KARIMI, ATOUSA, JOUHARI, SHEYDA, & Ansaripour, Soheila. (2017). EFFICACY OF INTRAUTERINE INJECTION OF GRANULOCYTE COLONY STIMULATING FACTOR (G-CSF) ON TREATMENT OF UNEXPLAINED RECURRENT MISCARRIAGE: A PILOT RCT STUDY. JOURNAL OF REPRODUCTION AND INFERTILITY, 18(4), 379-385. SID. https://sid.ir/paper/720473/en

    Vancouver: Copy

    ZAFARDOUST SIMIN, AKHONDI MOHAMMAD MEHDI, SADEGHI MOHAMMAD REZA, MOHAMMADZADEH AFSANEH, KARIMI ATOUSA, JOUHARI SHEYDA, Ansaripour Soheila. EFFICACY OF INTRAUTERINE INJECTION OF GRANULOCYTE COLONY STIMULATING FACTOR (G-CSF) ON TREATMENT OF UNEXPLAINED RECURRENT MISCARRIAGE: A PILOT RCT STUDY. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2017;18(4):379-385. Available from: https://sid.ir/paper/720473/en

    IEEE: Copy

    SIMIN ZAFARDOUST, MOHAMMAD MEHDI AKHONDI, MOHAMMAD REZA SADEGHI, AFSANEH MOHAMMADZADEH, ATOUSA KARIMI, SHEYDA JOUHARI, and Soheila Ansaripour, “EFFICACY OF INTRAUTERINE INJECTION OF GRANULOCYTE COLONY STIMULATING FACTOR (G-CSF) ON TREATMENT OF UNEXPLAINED RECURRENT MISCARRIAGE: A PILOT RCT STUDY,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 18, no. 4, pp. 379–385, 2017, [Online]. Available: https://sid.ir/paper/720473/en

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