Minocycline through attenuation of oxidative stress and inflammatory response reduces the neuropathic pain in a rat model of chronic constriction injury

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ABBASZADEH ABOLFAZL; DARABI SAEIDEH; HASANVAND AMIN; Amini Khoei Hossein; Abbasnezhad Amir; CHOGHAKHORI RAZIEH; AALIEHPOUR ASGHAR

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2018 | Volume:21 | Issue:2 Page(s): 138-144

Download Full-Text

View:

205

Download:

144

Cites:

Information Journal Paper

Title

Minocycline through attenuation of oxidative stress and inflammatory response reduces the neuropathic pain in a rat model of chronic constriction injury

Author(s)

Keywords

Chronic constriction-Injury

Inflammatory response

Minocycline

Neuropathic pain

Oxidative stress

Rat

Abstract

Objective(s): Several lines of evidence showed that Minocycline possesses antioxidant and anti-inflammatory properties. This study aimed to demonstRate the effects of Minocycline in Rats subjected to chronic constriction injury (CCI). Materials and Methods: In this study four groups (n = 6– 8) of Rats were used as follows: Sham, CCI, CCI + Minocycline (MIN) 10 mg/Kg (IP) and CCI + MIN 30 mg/Kg (IP). On days 3, 7, 14, and 21 post-surgery hot-plate, acetone, and von Frey tests were carried out. Finally, Motor Nerve Conduction Velocity Evaluation (MNCV) assessment was performed and spinal cords were harvested in order to measure tissue concentRations of TNF_α , IL-1β , Glutathione peroxidase (GPx), Superoxide dismutase (SOD) and Malondialdehyde (MDA). Extent of perineural inflammation and damage around the sciatic nerve was histopathologically evaluated. Results: Our results demonstRated that CCI significantly caused hyperalgesia and allodynia twenty-one days after CCI. MIN attenuated heat hyperalgesia, cold and mechanical allodynia and MNCV in animals. MIN also decreased the levels of TNF_α and IL-1β . Antioxidative enzymes (SOD, MDA, and GPx) were restored following MIN treatment. Our findings showed that MIN decreased perineural inflammation around the sciatic nerve. According to the results, the Neuropathic pain reduced in the CCI hyperalgesia model using 30 mg/kg of Minocycline. Conclusion: It is suggested that antinociceptive effects of Minocycline might be mediated through the inhibition of Inflammatory response and attenuation of Oxidative stress.

Cites

No record.

References

No record.

Cite

APA: Copy

ABBASZADEH, ABOLFAZL, DARABI, SAEIDEH, HASANVAND, AMIN, Amini Khoei, Hossein, Abbasnezhad, Amir, CHOGHAKHORI, RAZIEH, & AALIEHPOUR, ASGHAR. (2018). Minocycline through attenuation of oxidative stress and inflammatory response reduces the neuropathic pain in a rat model of chronic constriction injury. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(2), 138-144. SID. https://sid.ir/paper/720689/en

Vancouver: Copy

ABBASZADEH ABOLFAZL, DARABI SAEIDEH, HASANVAND AMIN, Amini Khoei Hossein, Abbasnezhad Amir, CHOGHAKHORI RAZIEH, AALIEHPOUR ASGHAR. Minocycline through attenuation of oxidative stress and inflammatory response reduces the neuropathic pain in a rat model of chronic constriction injury. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(2):138-144. Available from: https://sid.ir/paper/720689/en

IEEE: Copy

ABOLFAZL ABBASZADEH, SAEIDEH DARABI, AMIN HASANVAND, Hossein Amini Khoei, Amir Abbasnezhad, RAZIEH CHOGHAKHORI, and ASGHAR AALIEHPOUR, “Minocycline through attenuation of oxidative stress and inflammatory response reduces the neuropathic pain in a rat model of chronic constriction injury,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 2, pp. 138–144, 2018, [Online]. Available: https://sid.ir/paper/720689/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops