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Information Journal Paper

Title

Evaluation of TNF-α and IL-6 mRNAs expressions in visceral and subcutaneous adipose tissues of polycystic ovarian rats and effects of resveratrol

Pages

  165-174

Abstract

 Objective(s): Some studies suggest that chronic low-grade inflammation is involved in insulin resistance in polycystic ovary syndrome (PCOS). This study assessed possible involvement of alteRation in expression of two pro-inflammatory factors, tumor necrosis factor-α (TNF-α ) and interleukin-6 (IL-6) in Adipose tissues of PCOS Rats in the impairment of insulin actions. Also, effects of resveRatrol as an anti-inflammatory agent were investigated. Materials and Methods: Fifteen female Wistar Rats (21 days old) were divided into three groups (n=5): Ι ) Control, П ) PCO-model-saline: served as PCOS Rats and to induce PCOS, received subcutaneously testosterone enanthate 1 mg/100 g body weight subcutaneously for 35 days, Ш ) PCO-model-resveRatrol, after receiving testosterone, received resveRatrol 10 mg/kg intraperitoneally for 28 days. The expression of TNF-α and IL-6 mRNAs in Adipose tissues was determined by the qRT-PCR method. Results: The IL-6 mRNA expression in the visceral Adipose tissue of PCOS Rats was increased in comparison to controls (P<0. 05). TNF-α and IL-6 mRNA expression in visceral and subcutaneous Adipose tissues of polycystic ovarian Rats was similar to controls. The expression of TNF-α mRNA in subcutaneous Adipose tissue and TNF-α and IL-6 mRNAs in the visceral Adipose tissue of the PCO-model-resveRatrol group were lower than PCOS Rats (P<0. 05). Conclusion: Increased expression of IL-6 mRNA in the visceral Adipose tissue of polycystic ovarian Rats may be one cause of insulin resistance observed in them and resveRatrol as an anti-inflammatory and anti-hyperglycemic agent may decrease the risk of diabetes by reduction of expression of pro-inflammatory cytokines TNF-α and IL-6 in PCOS patients.

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    APA: Copy

    GHOWSI, MAHNAZ, KHAZALI, HOMAYOUN, & SISAKHTNEZHAD, SAJJAD. (2018). Evaluation of TNF-α and IL-6 mRNAs expressions in visceral and subcutaneous adipose tissues of polycystic ovarian rats and effects of resveratrol. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(2), 165-174. SID. https://sid.ir/paper/720690/en

    Vancouver: Copy

    GHOWSI MAHNAZ, KHAZALI HOMAYOUN, SISAKHTNEZHAD SAJJAD. Evaluation of TNF-α and IL-6 mRNAs expressions in visceral and subcutaneous adipose tissues of polycystic ovarian rats and effects of resveratrol. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(2):165-174. Available from: https://sid.ir/paper/720690/en

    IEEE: Copy

    MAHNAZ GHOWSI, HOMAYOUN KHAZALI, and SAJJAD SISAKHTNEZHAD, “Evaluation of TNF-α and IL-6 mRNAs expressions in visceral and subcutaneous adipose tissues of polycystic ovarian rats and effects of resveratrol,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 2, pp. 165–174, 2018, [Online]. Available: https://sid.ir/paper/720690/en

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