مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

203
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

126
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Time course of neuroprotection induced by in vivo normobaric hyperoxia preconditioning and angiogenesis factors

Pages

  67-74

Abstract

 Every year, a large number of people lose their lives due to Stroke. Stroke is the second leading cause of death worldwide. Surprisingly, recent studies have shown that preconditioning with hyperoxia (HO) increases tissue tolerance to ischemia, ultimately reducing damages caused by Stroke. Addressed in this study are beneficial contributions from HO preconditioning into reduced harm to be incurred by the attack, as well as its effect on the expression levels of Vascular endothelial growth factor (VEGF) and Endostatin. Materials and Methods: A set of experiments was conducted where a number of rats were divided into three groups. The animals in the first group received 90% oxygen for 4 hr a day, for 6 days. The second group was housed in room air and the third group was a sham (surgical stress). After 60 min of ischemia, 24 hr blood flow, neurological deficit score (NDS) and infarct volume (IV) in the group MCAO (Middle Cerebral Artery Occlusion) were investigated. Immediately following a 48 hr HO pre-treatment, sampling was performed to measure the expression levels of VEGF and Endostatin. Results: Preconditioning with alternating HO led to reduced infarct volume and NDS. Moreover, pre-treatment with HO resulted in increased VEGF expression while decreasing Endostatin. Conclusion: Although further studies are deemed necessary to clarify the mechanisms of Ischemic tolerance, apparently, somewhat intermittent hyperoxia can be associated with positive impacts by increasing VEGF and decreasing expression of Endostatin.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    Shahhoseini, Meisam, & BIGDELI, MOHAMMAD REZA. (2017). Time course of neuroprotection induced by in vivo normobaric hyperoxia preconditioning and angiogenesis factors. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(1), 67-74. SID. https://sid.ir/paper/720695/en

    Vancouver: Copy

    Shahhoseini Meisam, BIGDELI MOHAMMAD REZA. Time course of neuroprotection induced by in vivo normobaric hyperoxia preconditioning and angiogenesis factors. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(1):67-74. Available from: https://sid.ir/paper/720695/en

    IEEE: Copy

    Meisam Shahhoseini, and MOHAMMAD REZA BIGDELI, “Time course of neuroprotection induced by in vivo normobaric hyperoxia preconditioning and angiogenesis factors,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 1, pp. 67–74, 2017, [Online]. Available: https://sid.ir/paper/720695/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button