مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Emergence of signs of neural cells after exposure of bone marrow-derived mesenchymal stem cells to fetal brain extract

Pages

  301-307

Abstract

 Nowadays much effort is being invested in order to diagnose the mechanisms involved in neural Differentiation. By clarifying this, making desired Neural cells in vitro and applying them into diverse neurological disorders suffered from Neural cell malfunctions could be a feasible choice. Thus, the present study assessed the capability of Fetal brain extract (FBE) to induce rat bone marrow-derived mesenchymal stem cells (BM-MSCs) toward Neural cells. Materials and Methods: For this purpose, BM-MSCs were collected from rats and cultured and their mesenchymal properties were confirmed. After exposure of the BM-MSCs to Fetal brain extract, the cells were evaluated and harvested at days 3 and 7 after treatment. Results: The BM-MSCs that were exposed to FBE changed their appearance dramatically from spindle shape to cells with dendrite-like processes. Those neural like processes were absent in the control group. In addition, a neural specific marker, Vimentin, was expressed significantly in the treatment group but not in the negative control group. Conclusion: This study presented the FBE as a natural neural Differentiation agent, which probably has required factors for making neurons. In addition, Vimentin overexpression was observed in the treated group which confirms neuron-like cell Differentiation of BM-MSCs after induction.

Cites

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    • Cite

    APA: Copy

    Razeghian Jahromi, Iman, MEHRABANI, DAVOOD, MOHAMMADI, ALI, Ghahramani Seno, Mohammad Mahdi, DIANATPOUR, MEHDI, Zare, Shahrokh, & TAMADON, AMIN. (2017). Emergence of signs of neural cells after exposure of bone marrow-derived mesenchymal stem cells to fetal brain extract. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(3), 301-307. SID. https://sid.ir/paper/720706/en

    Vancouver: Copy

    Razeghian Jahromi Iman, MEHRABANI DAVOOD, MOHAMMADI ALI, Ghahramani Seno Mohammad Mahdi, DIANATPOUR MEHDI, Zare Shahrokh, TAMADON AMIN. Emergence of signs of neural cells after exposure of bone marrow-derived mesenchymal stem cells to fetal brain extract. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(3):301-307. Available from: https://sid.ir/paper/720706/en

    IEEE: Copy

    Iman Razeghian Jahromi, DAVOOD MEHRABANI, ALI MOHAMMADI, Mohammad Mahdi Ghahramani Seno, MEHDI DIANATPOUR, Shahrokh Zare, and AMIN TAMADON, “Emergence of signs of neural cells after exposure of bone marrow-derived mesenchymal stem cells to fetal brain extract,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 3, pp. 301–307, 2017, [Online]. Available: https://sid.ir/paper/720706/en

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