Bone marrow-derived mesenchymal stem cell and simvastatin treatment leads to improved functional recovery and modified c-Fos expression levels in the brain following ischemic stroke

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Pirzad Jahromi Gila; P. Shabanzadeh Alireza; MOKHTARI HASHTJINI MINA; Sadr Seyed Shahabeddin; Rasouli Vani Javad; raouf sarshoori Javad; Charish Jason

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2018 | Volume:21 | Issue:10 Page(s): 1004-1012

Download Full-Text

View:

261

Download:

157

Cites:

Information Journal Paper

Title

Bone marrow-derived mesenchymal stem cell and simvastatin treatment leads to improved functional recovery and modified c-Fos expression levels in the brain following ischemic stroke

Author(s)

Keywords

Behavioral assessment Bone marrow stromal cell Brain c

Fos Ischemic stroke Simvastatin

Abstract

Objective(s): The beneficial outcomes of bone marrow-derived mesenchymal stem cell (BMSC) treatment on functional recovery following stroke has been well established. Furthermore, 5-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors have also been shown to increase neuronal survival and promote the movement of BMSCs towards the sites of inflammation. However, the precise mechanisms mediating the improved neurological functional recovery in stoke models following a combination treatment of Simvastatin and BMSCs still remained poorly understood. Materials and Methods: Here, an embolic stroke model was used to experimentally induce a focal ischemic brain injury by inserting a preformed clot into the middle cerebral artery (MCA). Following stroke, animals were treated either with an intraperitoneal injection of Simvastatin, an intravenous injection of 3 ×106 BMSCs, or a combination of these two treatments. Results: Seven days after ischemia, the combination of Simvastatin and BMSCs led to a significant increase in BMSC relocation, endogenous neurogenesis, arteriogenesis and astrocyte activation while also reducing neuronal damage when compared to BMSC treatment alone (P<0. 001 for all). In addition, based on western blot analysis, following stroke there was a significant decrease in c-Fos expression (P<0. 001) in the combination treatment group. Conclusion: These results further demonstrate the synergistic benefits of a combination treatment and help to improve our understanding of the underlying mechanisms mediating this beneficial effect.

Cites

No record.

References

Cite

APA: Copy

Pirzad Jahromi, Gila, P. Shabanzadeh, Alireza, MOKHTARI HASHTJINI, MINA, Sadr, Seyed Shahabeddin, Rasouli Vani, Javad, raouf sarshoori, Javad, & Charish, Jason. (2018). Bone marrow-derived mesenchymal stem cell and simvastatin treatment leads to improved functional recovery and modified c-Fos expression levels in the brain following ischemic stroke. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(10), 1004-1012. SID. https://sid.ir/paper/720945/en

Vancouver: Copy

Pirzad Jahromi Gila, P. Shabanzadeh Alireza, MOKHTARI HASHTJINI MINA, Sadr Seyed Shahabeddin, Rasouli Vani Javad, raouf sarshoori Javad, Charish Jason. Bone marrow-derived mesenchymal stem cell and simvastatin treatment leads to improved functional recovery and modified c-Fos expression levels in the brain following ischemic stroke. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(10):1004-1012. Available from: https://sid.ir/paper/720945/en

IEEE: Copy

Gila Pirzad Jahromi, Alireza P. Shabanzadeh, MINA MOKHTARI HASHTJINI, Seyed Shahabeddin Sadr, Javad Rasouli Vani, Javad raouf sarshoori, and Jason Charish, “Bone marrow-derived mesenchymal stem cell and simvastatin treatment leads to improved functional recovery and modified c-Fos expression levels in the brain following ischemic stroke,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 10, pp. 1004–1012, 2018, [Online]. Available: https://sid.ir/paper/720945/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops