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Information Journal Paper

Title

Differential change in cortical and hippocampal monoamines, and behavioral patterns in streptozotocin-induced type 1 diabetic rats

Pages

  1026-1034

Abstract

 Objective(s): Diabetes mellitus (DM) is a widespread metabolic disorder worldwide. Clinical physicians have found diabetic patients have mild to middle cognitive dysfunction and an alteration of brain monoaminergic function. This study explored the change in various patterns of behavioral models and brain monoamine function under streptozotocin (STZ)-induced type 1 diabetes. Materials and Methods: We established a type 1 DM model via intravenous injection with STZ (65 mg/ kg) in rats. Three weeks after the STZ injection, various behavioral measurements including the inhibitory avoidance test, active avoidance test and Morris water maze were conducted. Finally, all rats were dissected and the concentrations of monoamines and their metabolites in cortex and Hippocampus were measured by high performance liquid chromatography with electrochemical detection. Results: We found that STZ induced type 1 diabetes (hyperglycemia and lack of insulin) in rats. STZinduced diabetic rats had cognitive impairment in acquisition sessions and long-term retention of the active avoidance test. STZ-induced diabetic rats also had cognitive impairment in spatial learning, reference and working memory of the Morris water maze. STZ significantly reduced concentrations of norepinephrine (NE) in the cortex and dopamine (DA) in the Hippocampus, but increased concentrations of DA and serotonin (5-HT) in the cortex 35 days after injection. The concentration of 5-HT in the Hippocampus was also significantly increased. Conclusion: The data suggested that this cognitive impairment after a short-term period of STZ injection might be related to cortical NE dysfunction, differential alteration of cortical and hippocampal DA function, and brain 5-HT hyperfunction.

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    Cite

    APA: Copy

    LIN, LI WEI, Tsai, Fan Shiu, Yang, Wen Ta, Lai, Shang Chih, Shih, Chun Chuan, Lee, Sheng Chi, & Wu, Chi Rei. (2018). Differential change in cortical and hippocampal monoamines, and behavioral patterns in streptozotocin-induced type 1 diabetic rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(10), 1026-1034. SID. https://sid.ir/paper/721214/en

    Vancouver: Copy

    LIN LI WEI, Tsai Fan Shiu, Yang Wen Ta, Lai Shang Chih, Shih Chun Chuan, Lee Sheng Chi, Wu Chi Rei. Differential change in cortical and hippocampal monoamines, and behavioral patterns in streptozotocin-induced type 1 diabetic rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(10):1026-1034. Available from: https://sid.ir/paper/721214/en

    IEEE: Copy

    LI WEI LIN, Fan Shiu Tsai, Wen Ta Yang, Shang Chih Lai, Chun Chuan Shih, Sheng Chi Lee, and Chi Rei Wu, “Differential change in cortical and hippocampal monoamines, and behavioral patterns in streptozotocin-induced type 1 diabetic rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 10, pp. 1026–1034, 2018, [Online]. Available: https://sid.ir/paper/721214/en

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