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Information Journal Paper

Title

Repression of TGF-β Signaling in Breast Cancer Cells by miR-302/367 Cluster

Pages

  444-450

Abstract

 Objective: Epigenetic alterations of the malignantly transformed cells have increasingly been regarded as an important event in the carcinogenic development. Induction of some miRNAs such as miR-302/367 cluster has been shown to induce Reprogramming of Breast Cancer cells and exert a tumor suppressive role by induction of mesenchymal to epithelial transition, apoptosis and a lower proliferation rate. Here, we aimed to investigate the impact of miR-302/367 overexpression on Transforming Growth Factor-Beta  (TGF-β ) signaling and how this may contribute to tumor suppressive effects of miR-302/367 cluster. Materials and Methods: In this experimental study, MDA-MB-231 and SK-BR-3 Breast Cancer cells were cultured and transfected with miR-302/367 expressing lentivector. The impact of miR-302/367 overexpression on several mediators of TGF-β signaling and cell cycle was assessed by quantitative real-time polymerase chain reaction (qPCR) and flow cytometry. Results: Ectopic expression of miR-302/367 cluster downregulated expression of some downstream elements of TGF-β pathway in MDA-MB-231 and SK-BR-3 Breast Cancer cell lines. Overexpression of miR-302/367 cluster inhibited proliferation of the Breast Cancer cells by suppressing the S-phase of cell cycle which was in accordance with inhibition of TGF-β pathway. Conclusion: TGF-β signaling is one of the key pathways in tumor progression and a general suppression of TGF-β mediators by the pleiotropically acting miR-302/367 cluster may be one of the important reasons for its anti-tumor effects in Breast Cancer cells.

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    Cite

    APA: Copy

    Ahmadalizadeh Khanehsar, Mona, Hoseinbeyki, Moslem, FAKHR TAHA, MASOUMEH, & JAVERI, ARASH. (2020). Repression of TGF-β Signaling in Breast Cancer Cells by miR-302/367 Cluster. CELL JOURNAL (YAKHTEH), 21(4), 444-450. SID. https://sid.ir/paper/721328/en

    Vancouver: Copy

    Ahmadalizadeh Khanehsar Mona, Hoseinbeyki Moslem, FAKHR TAHA MASOUMEH, JAVERI ARASH. Repression of TGF-β Signaling in Breast Cancer Cells by miR-302/367 Cluster. CELL JOURNAL (YAKHTEH)[Internet]. 2020;21(4):444-450. Available from: https://sid.ir/paper/721328/en

    IEEE: Copy

    Mona Ahmadalizadeh Khanehsar, Moslem Hoseinbeyki, MASOUMEH FAKHR TAHA, and ARASH JAVERI, “Repression of TGF-β Signaling in Breast Cancer Cells by miR-302/367 Cluster,” CELL JOURNAL (YAKHTEH), vol. 21, no. 4, pp. 444–450, 2020, [Online]. Available: https://sid.ir/paper/721328/en

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