Assessment of expressions of Bcl-XL, b-FGF, Bmp-2, Caspase-3, PDGFR-α , Smad1 and TGF-β 1 genes in a rat model of lung ischemia/reperfusion

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simsek Hasan; Demiryurek Seniz; Demir Tuncer; Atabay Husne Didem; ceribasi Ali Osman; Bayraktar Recep; Kaplan Davut Sinan; oztuzcu Serdar; Cengiz Beyhan

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Journal: Iranian Journal of Basic Medical Sciences Year:2016 | Volume:19 | Issue:2 Page(s): 209-214

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Title

Assessment of expressions of Bcl-XL, b-FGF, Bmp-2, Caspase-3, PDGFR-α , Smad1 and TGF-β 1 genes in a rat model of lung ischemia/reperfusion

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Keywords

Apoptosis

Growth factors

Ischemia/reperfusion

Lung

Abstract

Objective(s): Ischemia is described as organs and tissues are destitute of oxygen due to decreased arterial or venous blood flow. Many mechanisms play role in cell death happened as a consequence of a new blood flow is needed for both cell regeneration and to clean toxic metabolites during ischemia and later. Lung damage induced by Ischemia/reperfusion (I/R) is a frequent problem in Lung transplantation. Apoptosis (programmed cell death) is known as cell suicide, and plays a key role in embryonic developmental and in maintain adult tissue’ s life. Materials and Methods: It is investigated expressions of Smad1, Bmp-2, Bcl-XL, b-FGF, Caspase-3, TGF-β 1, PDGFR-α genes for molecular changes in Lung tissues, after I/R is formed, in this study. For this, we included 40 Wistar albino rats to this study and divided 4 groups (n=10). The Groups were determined as Control (C), Group 1= 1 hr ischemia (I), Group 2= 1 hr ischemia+2 hr reperfusion (I+2R), Group 3= 1 hr ischemia+4 hr reperfusion (I+4R). Besides, molecular analysis and histopathologic examinations of tissues were performed, and the results were evaluated by normalization and statistics analysis. Results: We have found a significant increase in expression of Bcl-XL (P=0. 046) and Caspase-3 (P=0. 026) genes of group 1, and it was not monitored any significant difference in Group 2 and Group 3. In all groups, the changes in b-FGF (P=0. 087), Bmp-2 (P=0. 457), TGF-β 1 (P=0. 201) and PDGFR-α (P=0. 116) were not significant compared to control group. We did not see any mRNA expression of Smad1 gene in all groups include control. Conclusion: These findings suggest that I/R injury may trigger apoptotic mechanism in Lung.

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APA: Copy

simsek, Hasan, Demiryurek, Seniz, Demir, Tuncer, Atabay, Husne Didem, ceribasi, Ali Osman, Bayraktar, Recep, Kaplan, Davut Sinan, oztuzcu, Serdar, & Cengiz, Beyhan. (2016). Assessment of expressions of Bcl-XL, b-FGF, Bmp-2, Caspase-3, PDGFR-α , Smad1 and TGF-β 1 genes in a rat model of lung ischemia/reperfusion. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(2), 209-214. SID. https://sid.ir/paper/721740/en

Vancouver: Copy

simsek Hasan, Demiryurek Seniz, Demir Tuncer, Atabay Husne Didem, ceribasi Ali Osman, Bayraktar Recep, Kaplan Davut Sinan, oztuzcu Serdar, Cengiz Beyhan. Assessment of expressions of Bcl-XL, b-FGF, Bmp-2, Caspase-3, PDGFR-α , Smad1 and TGF-β 1 genes in a rat model of lung ischemia/reperfusion. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(2):209-214. Available from: https://sid.ir/paper/721740/en

IEEE: Copy

Hasan simsek, Seniz Demiryurek, Tuncer Demir, Husne Didem Atabay, Ali Osman ceribasi, Recep Bayraktar, Davut Sinan Kaplan, Serdar oztuzcu, and Beyhan Cengiz, “Assessment of expressions of Bcl-XL, b-FGF, Bmp-2, Caspase-3, PDGFR-α , Smad1 and TGF-β 1 genes in a rat model of lung ischemia/reperfusion,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 2, pp. 209–214, 2016, [Online]. Available: https://sid.ir/paper/721740/en

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