Standardized Cannabis sativa extract attenuates tau and stathmin gene expression in the melanoma cell line

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VASEGHI GOLNAZ; Taki Mohamad Javad; HAGHJOOY JAVANMARD SHAGHAYEGH

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2017 | Volume:20 | Issue:10 Page(s): 1178-1181

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Title

Standardized Cannabis sativa extract attenuates tau and stathmin gene expression in the melanoma cell line

Author(s)

VASEGHI GOLNAZ | Taki Mohamad Javad | HAGHJOOY JAVANMARD SHAGHAYEGH | Issue Writer Certificate

Keywords

Cannabis plant extracts

Endothelial cells

Melanoma

Metastasis

Stathmin

Tau protein

Abstract

Objective(s): Metastasis is the main cause of death in patients with Melanoma. Cannabis-based medicines are effective adjunctive drugs in cancer patients. Tau and Stathmin proteins are the key proteins in cancer Metastasis. Here we have investigated the effect of a standardized Cannabis sativa extract on cell migration and Tau and Stathmin gene expression in the Melanoma cell line. Materials and Methods: In the treatment group, Melanoma (B1617) was treated 48 hr with various concentrations of standardized C. sativa extract. Cells with no treatment were considered as the control group, then study was followed by Quantitative RT-Real Time PCR assay. Relative gene expression was calculated by the Δ Δ ct method. Migration assay was used to evaluate cancer Metastasis. Results: Tau and Stathmin gene expression was significantly decreased compared to the control group. Cell migration was also significantly reduced compared to controls. Conclusion: C. sativa decreased tau and Stathmin gene expression and cancer Metastasis. The results may have some clinical relevance for the use of cannabis-based medicines in patients with metastatic Melanoma.

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APA: Copy

VASEGHI, GOLNAZ, Taki, Mohamad Javad, & HAGHJOOY JAVANMARD, SHAGHAYEGH. (2017). Standardized Cannabis sativa extract attenuates tau and stathmin gene expression in the melanoma cell line. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(10), 1178-1181. SID. https://sid.ir/paper/721770/en

Vancouver: Copy

VASEGHI GOLNAZ, Taki Mohamad Javad, HAGHJOOY JAVANMARD SHAGHAYEGH. Standardized Cannabis sativa extract attenuates tau and stathmin gene expression in the melanoma cell line. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(10):1178-1181. Available from: https://sid.ir/paper/721770/en

IEEE: Copy

GOLNAZ VASEGHI, Mohamad Javad Taki, and SHAGHAYEGH HAGHJOOY JAVANMARD, “Standardized Cannabis sativa extract attenuates tau and stathmin gene expression in the melanoma cell line,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 10, pp. 1178–1181, 2017, [Online]. Available: https://sid.ir/paper/721770/en

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