Molecular mechanisms regulating immune responses in thromboangiitis obliterans: A comprehensive review

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Shapouri Moghaddam Abbas; Saeed Modaghegh Mohammad Hadi; RAHIMI HAMID REZA; Ehteshamfar Seyyed Morteza; TAVAKOL AFSHARI JALIL

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:3 Page(s): 215-224

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Title

Molecular mechanisms regulating immune responses in thromboangiitis obliterans: A comprehensive review

Author(s)

Keywords

Angiogenesis

Immune system

Molecular biology

Signal pathways

Thromboangiitis

obliterans

Abstract

Thromboangiitis obliterans (TAO) is a thrombotic-occlusive as well as an inflammatory peripheral vascular disease with unknown etiology. Recent evidence has supported the immunopathogenesis of the disease, however, the factors contributing to the altered immune function and vascular tissue inflammation are still unclear. This review was intended to collate the more current knowledge on the regulatory molecules involved in TAO from an immunoreactive perspective. The homeostasis of the Immune system as well as a variety of progenitor cell populations appear to be affected during TAO and these alterations are associated with intrinsic signaling defects that are directing to an improved understanding of the crosstalk between Angiogenesis and the Immune system, as well as the potential of new co-targeting strategies applying both immunotherapy and angiogenic therapy.

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APA: Copy

Shapouri Moghaddam, Abbas, Saeed Modaghegh, Mohammad Hadi, RAHIMI, HAMID REZA, Ehteshamfar, Seyyed Morteza, & TAVAKOL AFSHARI, JALIL. (2019). Molecular mechanisms regulating immune responses in thromboangiitis obliterans: A comprehensive review. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(3), 215-224. SID. https://sid.ir/paper/721795/en

Vancouver: Copy

Shapouri Moghaddam Abbas, Saeed Modaghegh Mohammad Hadi, RAHIMI HAMID REZA, Ehteshamfar Seyyed Morteza, TAVAKOL AFSHARI JALIL. Molecular mechanisms regulating immune responses in thromboangiitis obliterans: A comprehensive review. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(3):215-224. Available from: https://sid.ir/paper/721795/en

IEEE: Copy

Abbas Shapouri Moghaddam, Mohammad Hadi Saeed Modaghegh, HAMID REZA RAHIMI, Seyyed Morteza Ehteshamfar, and JALIL TAVAKOL AFSHARI, “Molecular mechanisms regulating immune responses in thromboangiitis obliterans: A comprehensive review,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 3, pp. 215–224, 2019, [Online]. Available: https://sid.ir/paper/721795/en

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