Evaluation of lentinan effects on cytochrome P450 activity in rats by a cocktail method

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Lin Yiping; Wei Yanli; Hu Xiaoxia; Wu Meiling; Yao Jingchan; Ying Xiaoqian; Fu Xiaoyan; Ding Mingxing; Qiao Liman

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Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:3 Page(s): 296-301

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Title

Evaluation of lentinan effects on cytochrome P450 activity in rats by a cocktail method

Author(s)

Keywords

Cocktail

CYP

Herb-drug interaction

Lentinan

Probe drug

Abstract

Objective(s): In this study, a Cocktail of Probe drugs was used to assess whether Lentinan could influence the activities of rat enzymes CYP3A4, CYP2D6, CYP1A2, CYP2C19, and CYP2C9 in vivo. Materials and Methods: Fourteen days after intraperitoneal injection of Lentinan, rats were given an oral dose of a Cocktail solution containing phenacetin, tolbutamide, omeprazole, metoprolol, and midazolam. Then, we obtained blood in specific durations for the determination of plasma concentration of the Probe drugs using UPLC-MS/MS. We also evaluated the pharmacokinetic parameters using the DAS 2. 0 software. Results: We found that various concentrations of Lentinan increased the activity of rat CYP1A2, CYP3A4, CYP2D6, and CYP2C19 but not CYP2C9. Conclusion: These findings suggest that clinical application of Lentinan combination with CYP3A4, CYP1A2, CYP2C19, or CYP2D6 should be given careful consideration as this may lead to Herb-drug interactions and hence treatment failure.

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References

Effect of codeine on CYP450 isoform activity of rats

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APA: Copy

Lin, Yiping, Wei, Yanli, Hu, Xiaoxia, Wu, Meiling, Yao, Jingchan, Ying, Xiaoqian, Fu, Xiaoyan, Ding, Mingxing, & Qiao, Liman. (2019). Evaluation of lentinan effects on cytochrome P450 activity in rats by a cocktail method. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(3), 296-301. SID. https://sid.ir/paper/721796/en

Vancouver: Copy

Lin Yiping, Wei Yanli, Hu Xiaoxia, Wu Meiling, Yao Jingchan, Ying Xiaoqian, Fu Xiaoyan, Ding Mingxing, Qiao Liman. Evaluation of lentinan effects on cytochrome P450 activity in rats by a cocktail method. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(3):296-301. Available from: https://sid.ir/paper/721796/en

IEEE: Copy

Yiping Lin, Yanli Wei, Xiaoxia Hu, Meiling Wu, Jingchan Yao, Xiaoqian Ying, Xiaoyan Fu, Mingxing Ding, and Liman Qiao, “Evaluation of lentinan effects on cytochrome P450 activity in rats by a cocktail method,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 3, pp. 296–301, 2019, [Online]. Available: https://sid.ir/paper/721796/en

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