Low-frequency vibration treatment of bone marrow stromal cells induces bone repair in vivo

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He Shengwei; Zhao Wenzhi; ZHANG LU; Mi Lidong; Du Guangyu; Sun Chuanxiu; Sun Xuegang

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Journal: Iranian Journal of Basic Medical Sciences Year:2017 | Volume:20 | Issue:1 Page(s): 23-28

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Title

Low-frequency vibration treatment of bone marrow stromal cells induces bone repair in vivo

Author(s)

Keywords

Bone injury

Bone marrow stromal cells

Pre-Col1a

RUNX2

Vibration stress

Abstract

To study the effect of low-frequency vibration on bone marrow stromal cell differentiation and potential bone repair in vivo. Materials and Methods: Forty New Zealand rabbits were randomly divided into five groups with eight rabbits in each group. For each group, bone defects were generated in the left humerus of four rabbits, and in the right humerus of the other four rabbits. To test differentiation, bones were isolated and demineralized, supplemented with Bone marrow stromal cells, and implanted into humerus bone defects. Varying frequencies of vibration (0, 12. 5, 25, 50, and 100 Hz) were applied to each group for 30 min each day for four weeks. When the bone defects integrated, they were then removed for histological examination. mRNA transcript levels of runt-related transcription factor 2, osteoprotegerin, receptor activator of nuclear factor -B ligan, and pre-collagen type 1  were measured. Results: Humeri implanted with Bone marrow stromal cells displayed elevated callus levels and wider, more prevalent, and denser trabeculae following treatment at 25 and 50 Hz. The mRNA levels of runt-related transcription factor 2, osteoprotegerin, receptor activator of nuclear factor -B ligand, and pre-collagen type 1  were also markedly higher following 25 and 50 Hz treatment. Conclusion: Low frequency (25 50 Hz) vibration in vivo can promote bone marrow stromal cell differentiation and repair Bone injury.

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APA: Copy

He, Shengwei, Zhao, Wenzhi, ZHANG, LU, Mi, Lidong, Du, Guangyu, Sun, Chuanxiu, & Sun, Xuegang. (2017). Low-frequency vibration treatment of bone marrow stromal cells induces bone repair in vivo. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(1), 23-28. SID. https://sid.ir/paper/721882/en

Vancouver: Copy

He Shengwei, Zhao Wenzhi, ZHANG LU, Mi Lidong, Du Guangyu, Sun Chuanxiu, Sun Xuegang. Low-frequency vibration treatment of bone marrow stromal cells induces bone repair in vivo. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(1):23-28. Available from: https://sid.ir/paper/721882/en

IEEE: Copy

Shengwei He, Wenzhi Zhao, LU ZHANG, Lidong Mi, Guangyu Du, Chuanxiu Sun, and Xuegang Sun, “Low-frequency vibration treatment of bone marrow stromal cells induces bone repair in vivo,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 1, pp. 23–28, 2017, [Online]. Available: https://sid.ir/paper/721882/en

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