Anti-melanogenic activity of Viola odorata different extracts on B16F10 murine melanoma cells

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BARADARAN RAHIMI VAFA; ASKARI VAHID REZA; EMAMI SEYED AHMAD; TAYARANI NAJARAN ZAHRA

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Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2017 | Volume:20 | Issue:3 Page(s): 242-249

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Title

Anti-melanogenic activity of Viola odorata different extracts on B16F10 murine melanoma cells

Author(s)

BARADARAN RAHIMI VAFA | ASKARI VAHID REZA | EMAMI SEYED AHMAD | TAYARANI NAJARAN ZAHRA | Issue Writer Certificate

Keywords

B16F10 cell line

Melanin

ROS

Tyrosinase

Violaceae

Viola odorata L.

Abstract

In previous studies, antioxidant activity of Viola odorata L. has been demonstrated. In this study, we have investigated the anti-melanogenic effect of extract and fractions of the plant in B16F10 cell line. Materials and Methods: Impact of different increasing concentrations of extract and fractions of V. odorata was evaluated on cell viability, cellular Tyrosinase, Melanin content and mushroom Tyrosinase as well as ROS production in B16F10 murine melanoma cell line. Results: Viola odorata had no cytotoxicity on B16F10 cells compared to control group. Kojic acid as positive control had significant decreasing effects on cellular and mushroom Tyrosinase activity, Melanin content and ROS production (P<0. 001, for all cases). V. odorata (1-20 μ g/ml) decreased all measured parameters including cellular Tyrosinase and Melanin content as well as ROS production and among all extract and fractions ethyl acetate fraction had the best effect (P<0. 05). Conclusion: Viola odorata had promising anti-melanogenic activity through inhibition of cellular Tyrosinase activity and ROS production as well as Melanin content. More basic and clinical studies need to aver its impact.

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APA: Copy

BARADARAN RAHIMI, VAFA, ASKARI, VAHID REZA, EMAMI, SEYED AHMAD, & TAYARANI NAJARAN, ZAHRA. (2017). Anti-melanogenic activity of Viola odorata different extracts on B16F10 murine melanoma cells. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(3), 242-249. SID. https://sid.ir/paper/721891/en

Vancouver: Copy

BARADARAN RAHIMI VAFA, ASKARI VAHID REZA, EMAMI SEYED AHMAD, TAYARANI NAJARAN ZAHRA. Anti-melanogenic activity of Viola odorata different extracts on B16F10 murine melanoma cells. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(3):242-249. Available from: https://sid.ir/paper/721891/en

IEEE: Copy

VAFA BARADARAN RAHIMI, VAHID REZA ASKARI, SEYED AHMAD EMAMI, and ZAHRA TAYARANI NAJARAN, “Anti-melanogenic activity of Viola odorata different extracts on B16F10 murine melanoma cells,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 3, pp. 242–249, 2017, [Online]. Available: https://sid.ir/paper/721891/en

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