مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Survival, proliferation, and migration of human meningioma stem-like cells in a nanopeptide scaffold

Pages

  1271-1278

Abstract

 Objective(s): In order to grow cells in a three-dimensional (3D) microenvironment, self-assembling peptides, such as PuraMatrix, have emerged with potential to mimic the extracellular matrix. The aim of the present study was to investigate the influence of the self-assembling peptide on the morphology, survival, proliferation rate, migration potential, and differentiation of human meningioma stem-like cells (hMgSCs). Materials and Methods: The efficacy of a novel method for placing hMgSCs in PuraMatrix (the injection approach) was compared to the encapsulation and surface plating methods. In addition, we designed a new method for measurement of migration distance in 3D cultivation of hMgSCs in PuraMatrix. Results: Our results revealed that hMgSCs have the ability to form spheres in stem Cell culture condition. These meningioma cells expressed GFAP, CD133, vimentin, and nestin. Using the injection method, a higher proliferation rate of the hMgSCs was observed after seven days of culture. Furthermore, the novel migration assay was able to measure the migration of a single cell alone in 3D environment. Conclusion: The results indicate the injection method as an efficient technique for culturing hMgSCs in PuraMatrix. Furthermore, the novel migration assay enables us to evaluate the migration of hMgSCs.

Cites

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    • Cite

    APA: Copy

    SAHAB NEGAH, SAJAD, ALIGHOLI, HADI, KHAKSAR, ZABIHOLLAH, KAZEMI, HADI, MODARRES MOUSAVI, SAYED MOSTAFA, SAFAHANI, MARYAM, BARATI DOWOM, PARASTOO, & GORJI, ALI. (2016). Survival, proliferation, and migration of human meningioma stem-like cells in a nanopeptide scaffold. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(12), 1271-1278. SID. https://sid.ir/paper/722006/en

    Vancouver: Copy

    SAHAB NEGAH SAJAD, ALIGHOLI HADI, KHAKSAR ZABIHOLLAH, KAZEMI HADI, MODARRES MOUSAVI SAYED MOSTAFA, SAFAHANI MARYAM, BARATI DOWOM PARASTOO, GORJI ALI. Survival, proliferation, and migration of human meningioma stem-like cells in a nanopeptide scaffold. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(12):1271-1278. Available from: https://sid.ir/paper/722006/en

    IEEE: Copy

    SAJAD SAHAB NEGAH, HADI ALIGHOLI, ZABIHOLLAH KHAKSAR, HADI KAZEMI, SAYED MOSTAFA MODARRES MOUSAVI, MARYAM SAFAHANI, PARASTOO BARATI DOWOM, and ALI GORJI, “Survival, proliferation, and migration of human meningioma stem-like cells in a nanopeptide scaffold,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 12, pp. 1271–1278, 2016, [Online]. Available: https://sid.ir/paper/722006/en

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