Association of rs712 polymorphism in a let-7 microRNA-binding site of KRAS gene with colorectal cancer in a Mexican population

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Gallegos Arreola Martha Patricia; Zuniga Gonzalez Guillermo Moises; Gomez Mariscal Karen; Rosales Reynoso Monica Alejandra; Figuera Luis E.; Puebla Perez Ana Maria; Pineda Razo Tomas

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Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:3 Page(s): 324-327

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Title

Association of rs712 polymorphism in a let-7 microRNA-binding site of KRAS gene with colorectal cancer in a Mexican population

Author(s)

Keywords

Colorectal cancer

KRAS

let-7

Mexican population

Polymorphism

Abstract

Objective(s): The rs712 Polymorphism in a let-7 microRNA-binding site at KRAS gene has been associated with cancer. To examine its association with rs712 Polymorphism, we analyzed Mexican individuals with Colorectal cancer (CRC) and healthy subjects. Materials and Methods: Genotyping of the rs712 Polymorphism was performed by polymerase chain reaction in 281 controls and 336 CRC patients. Results: The observed frequencies of rs712 Polymorphism indicated an associated protective factor for CRC (P=0. 032). An association between genotype and the disease was evident in: colon localization (allele T, odds ratio (OR) 3. 82, 95% confidence Intervals (CI) 2. 77-5. 28, P=0. 0001), node metastasis (genotype TT, OR 2. 49, 95% CI 1. 45-4. 28, P=0. 0009), poor differentiation (genotype GT, OR 2. 35, 95% CI 1. 35-4. 1, P=0. 0033), and poor chemotherapy response (genotype GT, OR 2. 6, 95% CI 1. 7-4. 24, P=0. 0001). Conclusion: Comparison of the data from patients with control group showed that Polymorphism of rs712 in KRAS gene was protective factor, which was associated with susceptibility for CRC. However, the genotypes TT and GT of rs712 Polymorphism in KRAS could contribute significantly to colon localization, node metastasis, poor differentiation and poor chemotherapy response in CRC patients in this sample population.

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References

Significant association between Let-7-KRAS rs712 G > T polymorphism and cancer risk in the chinese population: a meta-analysis

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APA: Copy

Gallegos Arreola, Martha Patricia, Zuniga Gonzalez, Guillermo Moises, Gomez Mariscal, Karen, Rosales Reynoso, Monica Alejandra, Figuera, Luis E., Puebla Perez, Ana Maria, & Pineda Razo, Tomas. (2019). Association of rs712 polymorphism in a let-7 microRNA-binding site of KRAS gene with colorectal cancer in a Mexican population. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(3), 324-327. SID. https://sid.ir/paper/722255/en

Vancouver: Copy

Gallegos Arreola Martha Patricia, Zuniga Gonzalez Guillermo Moises, Gomez Mariscal Karen, Rosales Reynoso Monica Alejandra, Figuera Luis E., Puebla Perez Ana Maria, Pineda Razo Tomas. Association of rs712 polymorphism in a let-7 microRNA-binding site of KRAS gene with colorectal cancer in a Mexican population. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(3):324-327. Available from: https://sid.ir/paper/722255/en

IEEE: Copy

Martha Patricia Gallegos Arreola, Guillermo Moises Zuniga Gonzalez, Karen Gomez Mariscal, Monica Alejandra Rosales Reynoso, Luis E. Figuera, Ana Maria Puebla Perez, and Tomas Pineda Razo, “Association of rs712 polymorphism in a let-7 microRNA-binding site of KRAS gene with colorectal cancer in a Mexican population,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 3, pp. 324–327, 2019, [Online]. Available: https://sid.ir/paper/722255/en

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