Investigation of histopathological and radiological effects of surfactant treatment in an experimental female rat model of lung contusion

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Keskin Yasin; Bedel Cihan; Gokben Beceren Nesrin

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Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:10 Page(s): 1153-1157

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Title

Investigation of histopathological and radiological effects of surfactant treatment in an experimental female rat model of lung contusion

Author(s)

Keskin Yasin | Bedel Cihan | Gokben Beceren Nesrin | Issue Writer Certificate

Keywords

Blunt chest trauma

Chest trauma

Contusion

Lung contusion

Rat

Surfactant

Abstract

Objective(s): Pulmonary Contusion (PC) is a clinical entity that often accompanies blunt traumas. We aimed to investigate the radiological and histopathological effects of Surfactant treatment in an experimental Rat model in which lung Contusion was formed by blunt thoracic trauma. Materials and Methods: 50 female Sprague-Dawley Rats were used. Five groups were formed randomly. In groups 2, 4, and 5 lung Contusion was made by the drop-weight method after anesthesia. IntRatracheal Surfactant was administered in the 4th hr in groups 3 and 4 and in the 24th hr in groups 4 and 5. All Rats were sacrificed and their lungs removed at 48 hr after Contusion. Alveolar edema, congestion, hemorrhage, destruction, leukocyte infiltRation, immune staining were examined histopathologically. Results: When the first thoracic CT scans were evaluated, we observed two Rats with rib fractures and four Rats with pneumothorax. 4 and 48 hr thoracic CT evaluation Contusion and atelectasis showed no statistically significant decrease (P>0. 05). After sacrifice of group 2, in macroscopic evaluation, there was a heterogeneous Contusion and hemorrhagic appearance in the lungs of Rats and less hemorrhagic appearance was observed in Groups 4 and 5 than in Group 2. In comparison of Immunohistopathological findings, Surfactant treatment showed a statistically significant decrease in leukocyte infiltRation scores (P=0. 046). Immunohistopathologically, Surfactant group had more staining but only statistically significant when compared to groups 4 and sham. (P=0. 036). Conclusion: Surfactant treatment may be of significant benefit in lung Contusion secondary to Chest trauma/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">Blunt Chest trauma, and further prospective evidence of its efficacy in such disorders is needed.

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References

Evolution of surfactant therapy for respiratory distress syndrome: past, present, and future

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APA: Copy

Keskin, Yasin, Bedel, Cihan, & Gokben Beceren, Nesrin. (2019). Investigation of histopathological and radiological effects of surfactant treatment in an experimental female rat model of lung contusion. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(10), 1153-1157. SID. https://sid.ir/paper/722375/en

Vancouver: Copy

Keskin Yasin, Bedel Cihan, Gokben Beceren Nesrin. Investigation of histopathological and radiological effects of surfactant treatment in an experimental female rat model of lung contusion. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(10):1153-1157. Available from: https://sid.ir/paper/722375/en

IEEE: Copy

Yasin Keskin, Cihan Bedel, and Nesrin Gokben Beceren, “Investigation of histopathological and radiological effects of surfactant treatment in an experimental female rat model of lung contusion,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 10, pp. 1153–1157, 2019, [Online]. Available: https://sid.ir/paper/722375/en

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