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Information Journal Paper

Title

Catechol-o-methyltransferase inhibitor tolcapone improves learning and memory in naï ve but not in haloperidol challenged rats

Pages

  695-702

Abstract

 Objective(s): Dopamine plays an important role in cognitive functions. Inhibition of the Dopaminedegrading enzyme catechol-O-methyltransferase (COMT) may have beneficial effects. Our aim was to assess the effect of COMT inhibitor Tolcapone (TCP) on learning and memory in naï ve and haloperidolchallenged rats. Materials and Methods: Male Wistar rats were divided into 9 groups (n=8): naï ve-saline, Tolcapone 5; 15 and 30 mg/kg BW; haloperidol (HP) challenged-saline, haloperidol, haloperidol+Tolcapone 5; 15 and 30 mg/kg BW. Two-way active avoidance test (TWAA), elevated T-maze, and activity cage were performed. Observed parameters were: number of conditioned responses (CR) and unconditioned responses (UCR), Working memory index, and vertical and horizontal movements. Results: Naï ve rats with 30 mg/kg BW TCP had a significantly increased number of CR and UCR during the long-term memory test. The animals with 5 mg/kg BW TCP significantly increased the number of UCR during the two retention tests. In haloperidol-challenged rats, the three experimental groups decreased the number of CR and UCR during the learning session and the two memory tests, compared to the saline group. There was no significant difference between the HP-challenged rats treated with TCP and the haloperidol control group. All experimental naï ve groups had significantly increased Working memory index whereas none of the HP-challenged groups showed significant increase in this parameter. Conclusion: Our results demonstrate that in naï ve rats Tolcapone improves memory in the hippocampal-dependent TWAA task and spatial Working memory in T-maze.

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    APA: Copy

    Mihaylova, Anita, Zlatanova, Hristina, Doncheva, Nina, Delev, Delian, & Kostadinov, Ilia. (2019). Catechol-o-methyltransferase inhibitor tolcapone improves learning and memory in naï ve but not in haloperidol challenged rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(6), 695-702. SID. https://sid.ir/paper/722532/en

    Vancouver: Copy

    Mihaylova Anita, Zlatanova Hristina, Doncheva Nina, Delev Delian, Kostadinov Ilia. Catechol-o-methyltransferase inhibitor tolcapone improves learning and memory in naï ve but not in haloperidol challenged rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(6):695-702. Available from: https://sid.ir/paper/722532/en

    IEEE: Copy

    Anita Mihaylova, Hristina Zlatanova, Nina Doncheva, Delian Delev, and Ilia Kostadinov, “Catechol-o-methyltransferase inhibitor tolcapone improves learning and memory in naï ve but not in haloperidol challenged rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 6, pp. 695–702, 2019, [Online]. Available: https://sid.ir/paper/722532/en

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