مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

246
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

120
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress

Pages

  1238-1244

Abstract

 Objective(s): Obstructive sleep apnea (OSA) is confirmed to cause lesions in multiple organs, especially in the lung tissue. Tempol is an antioxidant that has been reported to restrain inflammation and Oxidative stress, with its role in OSA-induced lung injury being unclear. This study aimed to investigate the beneficial effect of Tempol on chronic Intermittent hypoxia (IH)-induced lung injury. Materials and Methods: A rat model of OSA was established by IH. There were four groups: normal air (NA), IH, IH+Tempol, NA+Tempol. Inflammatory response was evaluated by TNF-α , IL-1β , and IL-6 levels. Oxidative stress was detected by MDA and GSH levels, and SOD activity. The protein levels were assessed by Western blot. DNA binding activity of NF-κ B or Nrf2 was determined by electrophoretic mobility shift assay. Results: According to the results, Tempol administration alleviated pathological changes of the lung tissue, decreased leukocyte count and protein content (P<0. 001) in bronchoalveolar lavage fluid (BALF). Inflammation response in lung tissue induced by IH was suppressed by Tempol as evidenced by decreased levels of TNF-α , IL-1β , and IL-6 (P<0. 001) and protein levels of COX-2 and iNOS (P<0. 001). Moreover, Tempol inhibited Oxidative stress in lung tissue by down-regulating the MDA level (P<0. 001) and enhancing SOD activity (P<0. 001) and the GSH level (P<0. 05). In addition, Tempol repressed Inflammation response via inactivation of the NF-κ B pathway. Furthermore, the results suggested that Tempol repressed Oxidative stress by activating the Nrf2/HO-1 pathway. Conclusion: Our findings suggest that Tempol effectively relieves OSA-induced lung injury.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Hai, Bing, Ai, Li, Cao, Yue, Li, Ran, LI, HUI, & Li, Yongxia. (2018). Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(12), 1238-1244. SID. https://sid.ir/paper/722541/en

    Vancouver: Copy

    Hai Bing, Ai Li, Cao Yue, Li Ran, LI HUI, Li Yongxia. Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(12):1238-1244. Available from: https://sid.ir/paper/722541/en

    IEEE: Copy

    Bing Hai, Li Ai, Yue Cao, Ran Li, HUI LI, and Yongxia Li, “Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 12, pp. 1238–1244, 2018, [Online]. Available: https://sid.ir/paper/722541/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button