Identification of Mycobacterium tuberculosis adherence-mediating components: a review of key methods to confirm adhesin function

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Ramsugit Saiyur; Pillay Manormoney

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Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2016 | Volume:19 | Issue:6 Page(s): 579-584

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Information Journal Paper

Title

Identification of Mycobacterium tuberculosis adherence-mediating components: a review of key methods to confirm adhesin function

Author(s)

Ramsugit Saiyur | Pillay Manormoney | Issue Writer Certificate

Keywords

Adhesin

Mycobacterium –tuberculosis

Pathogenesis

Virulence factor

Abstract

Anti-adhesion therapy represents a potentially promising avenue for the treatment and prevention of tuberculosis in a post-antibiotic era. Adhesins are surface-exposed microbial structures or molecules that enable pathogenic organisms to adhere to host surfaces, a fundamental step towards host infection. Although several Mycobacterium tuberculosis Adhesins have been identified, it is predicted that numerous additional adherence-mediating components contribute to the virulence and success of this pathogen. Significant further research to discern and characterize novel M. tuberculosis Adhesins is, therefore, required to gain a holistic account of M. tuberculosis adhesion to the host. This would enable the identification of potential drug and vaccine targets for attenuating M. tuberculosis adherence and infectivity. Several methods have been successfully applied to the study and identification of M. tuberculosis Adhesins. In this manuscript, we review these methods, which include adherence assays that utilize wild-type and gene knockout mutant strains, epitope masking and competitive inhibition analyses, extracellular matrix protein binding assays, microsphere adhesion assays, M. tuberculosis auto-aggregation assays, and in silico analyses.

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APA: Copy

Ramsugit, Saiyur, & Pillay, Manormoney. (2016). Identification of Mycobacterium tuberculosis adherence-mediating components: a review of key methods to confirm adhesin function. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(6), 579-584. SID. https://sid.ir/paper/722669/en

Vancouver: Copy

Ramsugit Saiyur, Pillay Manormoney. Identification of Mycobacterium tuberculosis adherence-mediating components: a review of key methods to confirm adhesin function. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(6):579-584. Available from: https://sid.ir/paper/722669/en

IEEE: Copy

Saiyur Ramsugit, and Manormoney Pillay, “Identification of Mycobacterium tuberculosis adherence-mediating components: a review of key methods to confirm adhesin function,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 6, pp. 579–584, 2016, [Online]. Available: https://sid.ir/paper/722669/en

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