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Information Journal Paper

Title

Lack of Association between PTPN22 (+1858 C>T) rs2476601 polymorphism and susceptibility to rheumatoid arthritis (RA) in Northeast of Iran

Pages

  40-47

Keywords

Protein tyrosine phosphatase non-receptor type 22 (PTPN22) 

Abstract

 Background and objectives: Rheumatoid arthritis (RA) is an autoimmune disease with a complex genetic background. The protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a lymphoid specific protein tyrosine phosphatase which is involved in negative regulation of T cell response. Several studies have assessed the association between PTPN22 single nucleotide polymorphisms (SNPs) with RA susceptibility. Here, we aimed to assess the association of PTPN22 (1858 C>T) variant with the susceptibility to RA in northeast of Iran. Methods: A total of 127 RA patients and 119 age-and sex-matched healthy donors were enrolled. The polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) technique (PCR-RFLP) was applied to detect PTPN22 (1858 C>T) SNP. SPSS 22. 0 software was used to analyze data using relevant statistical tests. Results: Comparison of allele and genotype frequencies of PTPN22 (1858 C>T) SNP in RA patients and healthy donors revealed no significant association with RA susceptibility. Conclusion: The present study suggests that the PTPN22 (1858 C>T) genetic variants are not associated with RA susceptibility and disease activity. While this is the first report from northeast of Iran, further studies are needed to confirm these findings.

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    APA: Copy

    Ghovanjzadeh, sahar, Bazzazi, hadi, & YAZDANI, YAGHOUB. (2018). Lack of Association between PTPN22 (+1858 C>T) rs2476601 polymorphism and susceptibility to rheumatoid arthritis (RA) in Northeast of Iran. JORJANI BIOMEDICINE JOURNAL, 6(3), 40-47. SID. https://sid.ir/paper/722893/en

    Vancouver: Copy

    Ghovanjzadeh sahar, Bazzazi hadi, YAZDANI YAGHOUB. Lack of Association between PTPN22 (+1858 C>T) rs2476601 polymorphism and susceptibility to rheumatoid arthritis (RA) in Northeast of Iran. JORJANI BIOMEDICINE JOURNAL[Internet]. 2018;6(3):40-47. Available from: https://sid.ir/paper/722893/en

    IEEE: Copy

    sahar Ghovanjzadeh, hadi Bazzazi, and YAGHOUB YAZDANI, “Lack of Association between PTPN22 (+1858 C>T) rs2476601 polymorphism and susceptibility to rheumatoid arthritis (RA) in Northeast of Iran,” JORJANI BIOMEDICINE JOURNAL, vol. 6, no. 3, pp. 40–47, 2018, [Online]. Available: https://sid.ir/paper/722893/en

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