Increased Expression of Bax and Bcl2 Apoptosis Biomarkers in the Heart of Old Female Rats after Interval Training and Curcumin Consumption

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Yazdanparast Chaharmahali Bahareh; AZARBAYJANI MOHAMMAD ALI; Peeri Maghsood; Farzanegi Arkhazloo Parvin

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Journal: JORJANI BIOMEDICINE JOURNAL Year:2018 | Volume:6 | Issue:4 Page(s): 40-52

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Title

Increased Expression of Bax and Bcl2 Apoptosis Biomarkers in the Heart of Old Female Rats after Interval Training and Curcumin Consumption

Author(s)

Yazdanparast Chaharmahali Bahareh | AZARBAYJANI MOHAMMAD ALI | Peeri Maghsood | Farzanegi Arkhazloo Parvin | Issue Writer Certificate

Keywords

Apoptosis

Interval training

Rat

Curcumin

Heart

Abstract

Background and objectives: Elderly is characterized by decreased cardiac function, which is widely associated with mitochondrial failure in cell death. Elderly causes Heart Apoptosis. Although the old Heart is vulnerable to Apoptosis, physical training and some supplements through different mechanisms could be effective in reducing Apoptosis. The present study aimed to investigate the effect of Interval training on some apoptotic parameters of Bax and Bcl2 cardiomyocytes in old female Rats. Methods: In an experimental study, 49 Wistar female Rats (2 years old) were randomly assigned into 7 groups: control, saline, Curcumin, modeRate intensity training, modeRate intensity training + Curcumin, high intensity training, high intensity training + Curcumin. The experimental groups received gavage doses of Curcumin 30 mg / kg body weight three days a week via. The saline group also received the same amount of saline. Training groups had modeRate and severe exercises on the treadmill for eight weeks, and three sessions per week. Forty-eight hours after the last training session and gavage, the animals were killed and their Heart tissues were isolated to determine the levels of Bax and Bcl2. Results: The results indicated that Interval training and Curcumin consumption could significantly increase the levels of Bcl2 and BAX and the BAX / Bcl2 Ratio, the amount of which depends on the intensity of training. Moreover, the combination of training and Curcumin had an antagonistic effect. Conclusion: According to the results, physical activity and Curcumin sepaRately have a protective effect on the Heart tissue; however, these two interventions do not enhance each other’ s effect. Hence each one is suggested to be used sepaRately.

Cites

The Effects of Continued Training and High Intensity Interval Training along with Citrus Aurantium on Aerobic Power, Heart Weight, Adipose Tissue Weight and Body Weight of Elderly Rats

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APA: Copy

Yazdanparast Chaharmahali, Bahareh, AZARBAYJANI, MOHAMMAD ALI, Peeri, Maghsood, & Farzanegi Arkhazloo, Parvin. (2018). Increased Expression of Bax and Bcl2 Apoptosis Biomarkers in the Heart of Old Female Rats after Interval Training and Curcumin Consumption. JORJANI BIOMEDICINE JOURNAL, 6(4), 40-52. SID. https://sid.ir/paper/723169/en

Vancouver: Copy

Yazdanparast Chaharmahali Bahareh, AZARBAYJANI MOHAMMAD ALI, Peeri Maghsood, Farzanegi Arkhazloo Parvin. Increased Expression of Bax and Bcl2 Apoptosis Biomarkers in the Heart of Old Female Rats after Interval Training and Curcumin Consumption. JORJANI BIOMEDICINE JOURNAL[Internet]. 2018;6(4):40-52. Available from: https://sid.ir/paper/723169/en

IEEE: Copy

Bahareh Yazdanparast Chaharmahali, MOHAMMAD ALI AZARBAYJANI, Maghsood Peeri, and Parvin Farzanegi Arkhazloo, “Increased Expression of Bax and Bcl2 Apoptosis Biomarkers in the Heart of Old Female Rats after Interval Training and Curcumin Consumption,” JORJANI BIOMEDICINE JOURNAL, vol. 6, no. 4, pp. 40–52, 2018, [Online]. Available: https://sid.ir/paper/723169/en

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