مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Physicochemical and pharmacological evaluation of carvediloleudragit ® RS100 electrosprayed nanostructures

Pages

  547-556

Abstract

 Objective(s): This study was carried out to boost the pharmacologic influence of Carvedilol (CAR) (as a poorly water-soluble drug) by developing CAR-eudragit® RS100 (Eud) Nanofibers and Nanobeads benefiting an Electrospraying approach. Materials and Methods: CAR-Eud nanoformulations with varying ratios (1: 5 and 1: 10) at total solution concentrations of 10 %, 15 % and 20 % w/v were formulated. Results: The solution concentration remarkably impressed the size and morphology of the samples; in which, the Nanobeads (mean diameter of 135. 83 nm) were formed at low solution concentrations and high concentrations led to Nanofibers (mean diameter of 193. 45 nm) formation. DSC thermographs and PXRD patterns along with FTIR spectrum precisely showed CAR amorphization and no probable chemical interactions between CAR and Eud in the Electrosprayed nanosystems. The in vitro release considerations demonstrated that the nanoformulations with the drug: polymer ratios of 1: 10 and 1: 5 depict rapid dissolution rate compared to the physical mixtures (PMs) and the pure drug. The in vivo studies in Wistar male rats suggested that the Electrosprayed nanoformulation (1: 10; 20 %) reduced the isoproterenol (ISO) induced elevation of heart rate, necrosis and accumulation of neutrophils in the heart tissue more efficient than the pure drug and PM. Conclusion: Our finding illustrated that the Electrospraying as a profitable one-step procedure could be productively benefited to improve the physicochemical features and pharmacologic influences of CAR.

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    Cite

    APA: Copy

    SELSELEHJONBAN, SEVIL, GARJANI, ALIREZA, OSOULI BOSTANABAD, KARIM, Tanhaei, Ali, EMAMI, SHAHRAM, ADIBKIA, KHOSRO, & BARZEGAR JALALI, MOHAMMAD. (2019). Physicochemical and pharmacological evaluation of carvediloleudragit ® RS100 electrosprayed nanostructures. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(5), 547-556. SID. https://sid.ir/paper/723363/en

    Vancouver: Copy

    SELSELEHJONBAN SEVIL, GARJANI ALIREZA, OSOULI BOSTANABAD KARIM, Tanhaei Ali, EMAMI SHAHRAM, ADIBKIA KHOSRO, BARZEGAR JALALI MOHAMMAD. Physicochemical and pharmacological evaluation of carvediloleudragit ® RS100 electrosprayed nanostructures. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(5):547-556. Available from: https://sid.ir/paper/723363/en

    IEEE: Copy

    SEVIL SELSELEHJONBAN, ALIREZA GARJANI, KARIM OSOULI BOSTANABAD, Ali Tanhaei, SHAHRAM EMAMI, KHOSRO ADIBKIA, and MOHAMMAD BARZEGAR JALALI, “Physicochemical and pharmacological evaluation of carvediloleudragit ® RS100 electrosprayed nanostructures,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 5, pp. 547–556, 2019, [Online]. Available: https://sid.ir/paper/723363/en

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