مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

278
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

158
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Akt inhibitor deguelin aggravates inflammation and fibrosis in myocarditis

Pages

  1275-1282

Abstract

 Objective(s): Myocarditis is characterized by inflammatory cell infiltration in myocardial stroma. Attenuation of tumor necrosis factor (TNF)-α and interleukin (IL)-1β is a reliable mark for improving the prognosis. Protein kinase B (Akt) plays an important role in the development and progression of Myocarditis. The specific role of the natural inhibitor of Akt, Deguelin, on Myocarditis has not been reported. In this study, we used Deguelin to investigate the effects of natural Akt inhibitor on Myocarditis in experimental autoimmune Myocarditis (EAM) rats. Materials and Methods: EAM rat models were made by using Lewis rats and Deguelin was injected intraperitoneally on day 3, 6, 9, 12 and 15 after successful modeling. On day 18, rats were sacrificed and the heart weight (HW)/ body weight (BW) ratio were measured. The pathological changes, pathological scores and Fibrosis area were evaluated after H. &E. and Masson’ s trichrome staining. The mRNA levels of TNF-α and IL-1β were measured by RT-qPCR, while the protein expressions of TNF-α and IL-1β were detected by immunohistochemical staining and Western bolt. The protein expressions of Akt, Akt1, phosphorylated (p-) Akt and nuclear factor (NF)-κ B were detected by Western bolt. Results: We found that the TNF-α and IL-1β levels, inflammatory scores and Fibrosis areas were markedly increased after 18 days Deguelin administration. Conclusion: Akt inhibition with Deguelin may aggravate Myocarditis of EAM rats.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    LI, SHANSHAN, WANG, YUE, Zhao, Chunming, Zhang, Meixiang, WANG, WEI, Yu, Xiaowei, Huang, Jiao, WANG, ZHAO, Zhu, Bo, Yin, Chengqian, & Cai, Hongxing. (2019). Akt inhibitor deguelin aggravates inflammation and fibrosis in myocarditis. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(11), 1275-1282. SID. https://sid.ir/paper/723388/en

    Vancouver: Copy

    LI SHANSHAN, WANG YUE, Zhao Chunming, Zhang Meixiang, WANG WEI, Yu Xiaowei, Huang Jiao, WANG ZHAO, Zhu Bo, Yin Chengqian, Cai Hongxing. Akt inhibitor deguelin aggravates inflammation and fibrosis in myocarditis. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(11):1275-1282. Available from: https://sid.ir/paper/723388/en

    IEEE: Copy

    SHANSHAN LI, YUE WANG, Chunming Zhao, Meixiang Zhang, WEI WANG, Xiaowei Yu, Jiao Huang, ZHAO WANG, Bo Zhu, Chengqian Yin, and Hongxing Cai, “Akt inhibitor deguelin aggravates inflammation and fibrosis in myocarditis,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 11, pp. 1275–1282, 2019, [Online]. Available: https://sid.ir/paper/723388/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button