A novel atheroprotective role of MF59-like adjuvant when co-administered with CETP vaccine in rabbit model of atherosclerosis

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AGHEBATI TAMARA; MOHAMMADPOUR AMIR HOOSHANG; AFSHAR MOHAMMAD; JAAFARI MAHMOUD REZA; ABNOUS KHALIL; Nazemi Saeed; Issazadeh Sobhan; Hashemzadeh Saeed; ZARE MOHAMMAD; BADIEE ALI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2016 | Volume:19 | Issue:12 Page(s): 1345-1352

Download Full-Text

View:

261

Download:

Cites:

Information Journal Paper

Title

A novel atheroprotective role of MF59-like adjuvant when co-administered with CETP vaccine in rabbit model of atherosclerosis

Author(s)

Keywords

Alum/CpG

Atherosclerosis

Cardiovascular disease CETP vaccine

MF59

Abstract

Objective(s): In this study, for the first time, MF59 adjuvant was used to develop a cholesteryl ester transfer protein (CETP) vaccine. The efficacy of the vaccine was compared with the efficacy of CETP vaccine formulated with Alum/CpG, the formulation that its immunogenicity has been already demonstrated in rabbit and mice. Materials and Methods: Tetanus toxoid-CETP peptide (TT-CETP) was mixed with Alum/CpG or MF59-like and administered subcutaneously for total five times in rabbit model of Atherosclerosis. Anti-TT-CETP specific antibody, CETP activity in sera and mRNA level of cytokine IL-4 and IFN-γ in peripheral mononuclear cells were determined. Therapeutic response was also examined by tracking serum lipoprotein levels and pathologic observation of atherosclerotic lesions at aortic site. Results: More anti-TT-CETP antibody was found in Alum/CpG vaccinated rabbits compared to buffer (P<0. 001). Antibody induced by MF59-like formulation was not significantly higher than buffer. CETP activity and lipoprotein levels were not significantly different between vaccinated and control rabbits. The mRNA level of IL-4 was significantly lower than buffer while, IFN-γ gene expression was significantly higher in both vaccinated groups. Atherosclerosis thickness grade of aorta was dramatically lower than buffer (P<0. 01) in both vaccinated groups. Conclusion: It is concluded that MF59-adjuvanted CETP vaccine showed anti-Atherosclerosis properties, but the protective effect could not be directly attributed to the immune response induced by anti TT-CETP antibody and CETP inhibition. Further studies are needed to explain the anti-Atherosclerosis properties of MF59 in the presence of TT-CETP peptide.

Cites

No record.

References

No record.

Cite

APA: Copy

AGHEBATI, TAMARA, MOHAMMADPOUR, AMIR HOOSHANG, AFSHAR, MOHAMMAD, JAAFARI, MAHMOUD REZA, ABNOUS, KHALIL, Nazemi, Saeed, Issazadeh, Sobhan, Hashemzadeh, Saeed, ZARE, MOHAMMAD, & BADIEE, ALI. (2016). A novel atheroprotective role of MF59-like adjuvant when co-administered with CETP vaccine in rabbit model of atherosclerosis. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(12), 1345-1352. SID. https://sid.ir/paper/723630/en

Vancouver: Copy

AGHEBATI TAMARA, MOHAMMADPOUR AMIR HOOSHANG, AFSHAR MOHAMMAD, JAAFARI MAHMOUD REZA, ABNOUS KHALIL, Nazemi Saeed, Issazadeh Sobhan, Hashemzadeh Saeed, ZARE MOHAMMAD, BADIEE ALI. A novel atheroprotective role of MF59-like adjuvant when co-administered with CETP vaccine in rabbit model of atherosclerosis. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(12):1345-1352. Available from: https://sid.ir/paper/723630/en

IEEE: Copy

TAMARA AGHEBATI, AMIR HOOSHANG MOHAMMADPOUR, MOHAMMAD AFSHAR, MAHMOUD REZA JAAFARI, KHALIL ABNOUS, Saeed Nazemi, Sobhan Issazadeh, Saeed Hashemzadeh, MOHAMMAD ZARE, and ALI BADIEE, “A novel atheroprotective role of MF59-like adjuvant when co-administered with CETP vaccine in rabbit model of atherosclerosis,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 12, pp. 1345–1352, 2016, [Online]. Available: https://sid.ir/paper/723630/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops