مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

223
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

97
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Vitamin D3 attenuates oxidative stress and cognitive deficits in a model of toxic demyelination

Pages

  80-88

Abstract

 Objective(s): Multiple Sclerosis (MS) is a demyelinating disease. The prevalence of MS is highest where environmental supplies of vitamin D are low. Cognitive deficits have been observed in patients with MS. Oxidative damage may contribute to the formation of MS lesions. Considering the involvement of hippocampus in MS, an attempt is made in this study to investigate the effects of Vitamin D3 on behavioral process and the oxidative status in the dorsal hippocampus (CA1 area) following the induction of experimental demyelination in rats. Materials and Methods: Animals were divided into six groups. Control group: animals received no surgery and treatment; saline group: animals received normal saline; sham group: animals received 150 μ l sesame oil IP; Vitamin D3 group: animals received 5 μ g/kg Vitamin D3 IP; lysophosphatidyl choline (LPC) group (toxic demyelination’ s model): animals received LPC by stereotaxic intrahippocampal injection of 2 μ l LPC in CA1 area; Vitamin D3‐ treated group: animals were treated with Vitamin D3 at doses of 5 μ g/kg IP for 7 and 21 days post lesion. The spatial memory, biochemical parameters including catalase (CAT) activities and lipid peroxidation levels were investigated. Results: Animals in LPC group had more deficits in spatial memory than the control group in radial arm maze. Vitamin D3 significantly improved spatial memory compared to LPC group. Also, results indicated that Vitamin D3 caused a decrease in lipid peroxidation levels and an increase in CAT activities. Conclusion: Current findings suggest that Vitamin D3 may have a protective effect on cognitive deficits and Oxidative stress in toxic demyelination’ s model.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    Tarbali, Sepideh, & KHEZRI, SHIVA. (2016). Vitamin D3 attenuates oxidative stress and cognitive deficits in a model of toxic demyelination. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(1), 80-88. SID. https://sid.ir/paper/723714/en

    Vancouver: Copy

    Tarbali Sepideh, KHEZRI SHIVA. Vitamin D3 attenuates oxidative stress and cognitive deficits in a model of toxic demyelination. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(1):80-88. Available from: https://sid.ir/paper/723714/en

    IEEE: Copy

    Sepideh Tarbali, and SHIVA KHEZRI, “Vitamin D3 attenuates oxidative stress and cognitive deficits in a model of toxic demyelination,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 1, pp. 80–88, 2016, [Online]. Available: https://sid.ir/paper/723714/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button