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Information Journal Paper

Title

Immunology and Genetic of Leishmania infantum: The Role of Endonuclease G in the Apoptosis

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  0-0

Abstract

 Leishmania infantum is the causative agent of infantile visceral leishmaniasis (VL) in the Mediterranean region. Despite developing protective responses, the disease progresses due to many of factors. These include the action of suppressive cytokines, exhaustion of specific T cells, loss of lymphoid tissue, and defective humoral response. Genetic changes that occur inside the genome of alienated or parasite cells, along with immune responses, play an important role in controlling or progressing the disease. Proapoptotic proteins such as Smac/DIABLO, EndoG, AIF (Apoptosis‑ inducing factor), and cytochrome C are effective in Apoptosis. EndoG is a mitochondrion‑ specific nuclease that translocates to the nucleus during Apoptosis. Once released from mitochondria, endoG cleaves chromatin DNA into nucleosomal fragments independently of caspases. Therefore, endoG represents a caspase‑ independent apoptotic pathway initiated from the mitochondria. A comprehensive understanding of the immune and genetic events that occur during VL is very important for designing immunotherapy strategies and developing effective vaccines for disease prevention. In this review which explained the immunological responses and also the important factors that can contribute to parasite Apoptosis and are used in subsequent studies as a target for the preparation of drugs or recombinant vaccines against parasites are briefly reviewed.

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    APA: Copy

    AZAMI, MEHDI, Ranjkesh Adermanabadi, Vahid, KHANAHMAD, HOSSEIN, Mohaghegh, Mohammad Ali, Zaherinejad, Ebtesam, AGHAEI, MARYAM, JALALI, AKRAM, & HEJAZI, SEYED HOSSEIN. (2018). Immunology and Genetic of Leishmania infantum: The Role of Endonuclease G in the Apoptosis. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 23(4), 0-0. SID. https://sid.ir/paper/724247/en

    Vancouver: Copy

    AZAMI MEHDI, Ranjkesh Adermanabadi Vahid, KHANAHMAD HOSSEIN, Mohaghegh Mohammad Ali, Zaherinejad Ebtesam, AGHAEI MARYAM, JALALI AKRAM, HEJAZI SEYED HOSSEIN. Immunology and Genetic of Leishmania infantum: The Role of Endonuclease G in the Apoptosis. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2018;23(4):0-0. Available from: https://sid.ir/paper/724247/en

    IEEE: Copy

    MEHDI AZAMI, Vahid Ranjkesh Adermanabadi, HOSSEIN KHANAHMAD, Mohammad Ali Mohaghegh, Ebtesam Zaherinejad, MARYAM AGHAEI, AKRAM JALALI, and SEYED HOSSEIN HEJAZI, “Immunology and Genetic of Leishmania infantum: The Role of Endonuclease G in the Apoptosis,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 23, no. 4, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/724247/en

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