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Title

Methylglyoxal and insulin resistance in berberine‑ treated type 2 diabetic patients

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Abstract

 diabetes mellitus is a chronic metabolic disorder of hyperglycemia. Chronic hyperglycemia produces advanced glycation end products such as the methylglyoxal (MGO) which interferes with cell functions, insulin signaling, and β ‑ cell functions. The present study was conducted to determine the effects of Berberine (BBR) therapy on serum MGO and insulin resistance in newly diagnosed type 2 diabetic patients. Materials and Methods: The present case– control study was conducted at the Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro/Hyderabad, from March 2016 to January 2017. A sample of 200 newly diagnosed type 2 diabetic patients was divided into two groups. Group 1 received metformin 500 mg (×3 daily) and Group 2 received BBR 500 mg (×3 daily) for 3 months. Blood samples were collected at baseline and after 3 months to analyze biochemical parameters on Roche biochemical analyzer. MGO was assayed by ELISA kit and homeostasis model assessment of insulin resistance (HOMA‑ IR) model. SPSS version 23. 0 (IBM, Incorporation, USA) analyzed the data at 95% confidence interval (P ≤ 0. 05). Results: Baseline HOMA‑ IR (% IR) and MGO were found elevated in metformin and BBR groups. After 3 months of metformin and BBR therapy, the HOMA‑ IR (% IR) and MGO were decreased to 3. 69 ± 1. 13 and 2. 64 ± 0. 76 and 35. 84 ± 12. 56 and 26. 64 ± 10. 73 ng/ dl, respectively (P = 0. 0001). HOMA‑ IR (% IR) was improved by 40% and 73% (P = 0. 0001) and MGO by 43% and 56% in metformin and BBR groups, respectively (P = 0. 0001). Conclusion: BBR is more effective in decreasing the serum MGO levels and insulin resistance through improved glycemic control in newly diagnosed type 2 diabetic patients.

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    APA: Copy

    Memon, Muhammad Ayoob, Khan, Raisa Noor, Riaz, Saman, Ain, Qurat Ul, Ahmed, Masood, & Kumar, Naresh. (2018). Methylglyoxal and insulin resistance in berberine‑ treated type 2 diabetic patients. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 23(12), 0-0. SID. https://sid.ir/paper/724317/en

    Vancouver: Copy

    Memon Muhammad Ayoob, Khan Raisa Noor, Riaz Saman, Ain Qurat Ul, Ahmed Masood, Kumar Naresh. Methylglyoxal and insulin resistance in berberine‑ treated type 2 diabetic patients. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2018;23(12):0-0. Available from: https://sid.ir/paper/724317/en

    IEEE: Copy

    Muhammad Ayoob Memon, Raisa Noor Khan, Saman Riaz, Qurat Ul Ain, Masood Ahmed, and Naresh Kumar, “Methylglyoxal and insulin resistance in berberine‑ treated type 2 diabetic patients,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 23, no. 12, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/724317/en

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