Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

212
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

138
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Electroacupuncture attenuates chronic fibromyalgia pain through the phosphorylated phosphoinositide 3-kinase signaling pathway in the mouse brain

Pages

  1085-1090

Abstract

 Objective(s): Fibromyalgia (FM) is a central nervous system disorder characterized by widespread mechanical hyperalgesia due to unknown mechanisms. Several inflammatory mediators, such as interleukin-1 (IL-1), IL-6, IL-8, and tumor necrosis factor, are increased in the serum of FM patients. Although medications including pregabalin, duloxetine, and milnacipran are used to treat FM, the results are unsatisfying. In the present study we assessed whether Electroacupuncture (EA) can reduce chronic FM pain and then proposed an underlying mechanism for this effect. Materials and Methods: Chronic FM pain was induced in mice by dual acid saline injection lasting up to 4 weeks. Results: Chronic FM pain was treated by EA manipulation, but not in the sham operated group. Phosphorylated Phosphatidylinositol 3-kinase (pPI3K), protein kinase B, mechanistic target of rapamycin, and nuclear factor kappa-light-chain-enhancer of activated B cells were unaltered in the mouse Dorsal root ganglion (DRG) and spinal cord (SC) after inducing FM and administering EA treatment. The pPI3K-associated nociceptive signaling pathway was increased in the thalamus of FM mice, but reversed by EA. Similar results were observed in the mouse somatosensory cortex. Conclusion: These data suggest that EA has a significant effect on a signaling pathway in brain areas of FM mice. These findings suggest the value of EA for clinical practice.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Chen, Chao Tsung, Lin, Jaung Geng, Huang, Chun Ping, & Lin, Yi Wen. (2019). Electroacupuncture attenuates chronic fibromyalgia pain through the phosphorylated phosphoinositide 3-kinase signaling pathway in the mouse brain. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(9), 1085-1090. SID. https://sid.ir/paper/724470/en

    Vancouver: Copy

    Chen Chao Tsung, Lin Jaung Geng, Huang Chun Ping, Lin Yi Wen. Electroacupuncture attenuates chronic fibromyalgia pain through the phosphorylated phosphoinositide 3-kinase signaling pathway in the mouse brain. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(9):1085-1090. Available from: https://sid.ir/paper/724470/en

    IEEE: Copy

    Chao Tsung Chen, Jaung Geng Lin, Chun Ping Huang, and Yi Wen Lin, “Electroacupuncture attenuates chronic fibromyalgia pain through the phosphorylated phosphoinositide 3-kinase signaling pathway in the mouse brain,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 9, pp. 1085–1090, 2019, [Online]. Available: https://sid.ir/paper/724470/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top