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Information Journal Paper

Title

Prednison provokes serum and vasoactive substances in a mice model of immune thrombocytopenia

Pages

  1010-1015

Abstract

 Objective(s): The main objective of this study was to investigate the variations of β-endorphin (β-EP), vasoactive intestinal peptide (VIP), serotonin (5-HT) and norepinephrine (NE) of Immune thrombocytopenia (ITP) Mice as well as the regulatory mechanism of prednison. Materials and Methods: Sixty BALB/c Mice were randomly divided into control group, model group and prednison intervention group. ITP Mice model was duplicated by injecting with glycoprotein-antiplatelet serum (GP-APS) except in control group. After ITP disease model was successful established, prednison was used in prednison intervention group. The β-EP, VIP, 5-HT and NE contents of ITP Mice were detected by enzyme linked immunosorbent assay (ELISA). Results: Compared with the values in control group, the detection values of VIP and 5-HT in model group declined, while the detection values of β-EP and NE increased. Compared with prednison intervention group, the detection values of VIP and 5-HT in model group increased, while the detection values of β-EP and NE showed no significant change. Conclusion: In this study, the β-EP, VIP, 5-HT and NE contents in ITP Mice injected with GP-APS were changed by prednison. It shows that prednison as the first-line therapy for ITP with effective hemostasis function is likely to increasing the contents of VIP and 5-HT. These results suggest the therapeutic value of prednison for the treatment of ITP.

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    APA: Copy

    ZHANG, LING, Chen, Ke, Li, Tiantian, He, Hao, Hou, Li, Wu, Xiaoyong, Sun, Yanping, Zheng, Lei, Chen, Zhixiong, Qin, Bei, Chen, Xinyi, & Tian, Shaodan. (2016). Prednison provokes serum and vasoactive substances in a mice model of immune thrombocytopenia. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(9), 1010-1015. SID. https://sid.ir/paper/724976/en

    Vancouver: Copy

    ZHANG LING, Chen Ke, Li Tiantian, He Hao, Hou Li, Wu Xiaoyong, Sun Yanping, Zheng Lei, Chen Zhixiong, Qin Bei, Chen Xinyi, Tian Shaodan. Prednison provokes serum and vasoactive substances in a mice model of immune thrombocytopenia. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(9):1010-1015. Available from: https://sid.ir/paper/724976/en

    IEEE: Copy

    LING ZHANG, Ke Chen, Tiantian Li, Hao He, Li Hou, Xiaoyong Wu, Yanping Sun, Lei Zheng, Zhixiong Chen, Bei Qin, Xinyi Chen, and Shaodan Tian, “Prednison provokes serum and vasoactive substances in a mice model of immune thrombocytopenia,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 9, pp. 1010–1015, 2016, [Online]. Available: https://sid.ir/paper/724976/en

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