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Title

Recurrent Miscarriage and Implantation Failure of Unknown Cause Studied by a Panel of Thrombophilia Conditions: Increased Frequency of FXIII Val34Leu Polymorphism

Pages

  76-82

Abstract

 Background: The role of acquired Thrombophilia has been accepted as an etiology of recurrent Miscarriage (RM); however, the contribution of specific inherited throm-bophilic genes to this disorder has remained controversial. An increased incidence of RM has been suggested in women with inherited Thrombophilia. Methods: In this prospective study, assisted women with RM or repeated Implant failure (RIF) were subjected to Thromboincode analysis, in order to identify 12 ge-netic variants for Factor V Leiden, Factor V Hong Kong, Factor V Cambridge, FII, FXIII, FXII, and A1 carriers. Patients included in this study were separated in RM cases (n=43), RIF cases (n=36) and RIF+RM (n=76). As a control group, patients undergoing IVF treatment (n=34) were used and a previously described 249 cases population as a representative sample of Spanish population were selected. Level of statistical significance was p<0. 05 and groups were compared by Fisher test, except for age that was compared by t-test. Results: Regarding FXIII, higher values were observed in RM (69. 76%), RIF (70%) and in RM+RIF (68. 42%) group when compared with our control group (52. 94%) and general Spanish population (56. 5%), but these differences were statistically sig-nificant only in RIF group (p=0. 043, p=0. 01). Conclusion: Concerning our findings, both RM and RIF patients had a very similar panel of Thrombophilia polymorphisms, suggesting that, in both, Thrombophilia might have an important contribution. High frequency of Val34Leu polymorphism in RM/ RIF presumably speaks in favor of a multifactorial RM genesis, wherean altered Thrombophilia status plays a role.

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    APA: Copy

    DIAZ NUNEZ, MARIA, Rabanal, Aintzane, EXPOSITO, ANTONIA, FERRANDO, MARCOS, Quintana, Fernando, Manuel Soria, Jose, & MATORRAS, ROBERTO. (2019). Recurrent Miscarriage and Implantation Failure of Unknown Cause Studied by a Panel of Thrombophilia Conditions: Increased Frequency of FXIII Val34Leu Polymorphism. JOURNAL OF REPRODUCTION AND INFERTILITY, 20(2), 76-82. SID. https://sid.ir/paper/724992/en

    Vancouver: Copy

    DIAZ NUNEZ MARIA, Rabanal Aintzane, EXPOSITO ANTONIA, FERRANDO MARCOS, Quintana Fernando, Manuel Soria Jose, MATORRAS ROBERTO. Recurrent Miscarriage and Implantation Failure of Unknown Cause Studied by a Panel of Thrombophilia Conditions: Increased Frequency of FXIII Val34Leu Polymorphism. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2019;20(2):76-82. Available from: https://sid.ir/paper/724992/en

    IEEE: Copy

    MARIA DIAZ NUNEZ, Aintzane Rabanal, ANTONIA EXPOSITO, MARCOS FERRANDO, Fernando Quintana, Jose Manuel Soria, and ROBERTO MATORRAS, “Recurrent Miscarriage and Implantation Failure of Unknown Cause Studied by a Panel of Thrombophilia Conditions: Increased Frequency of FXIII Val34Leu Polymorphism,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 20, no. 2, pp. 76–82, 2019, [Online]. Available: https://sid.ir/paper/724992/en

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