Four main therapeutic keys for Parkinson’ s disease: A mini review

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Hernandez-Baltazar Daniel; Nadella Rasajna; Zavala Flores Laura Mireya; Rosas Jarquin Christian de Jesus; Rovirosa Hernandez Maria de Jesus; Villanueva Olivo Arnulfo

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:7 Page(s): 716-721

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Title

Four main therapeutic keys for Parkinson’ s disease: A mini review

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Keywords

Cell death

Dopaminergic neurons

Inflammation

Survival

Therapeutics

Abstract

Objective(s): Parkinson’ s disease (PD) is characterized by motor and cognitive dysfunctions. The progressive degeneration of dopamine-producing neurons that are present in the substantia nigra pars compacta (SNpc) has been the main focus of study and PD therapies since ages. Materials and Methods: In this manuscript, a systematic revision of experimental and clinical evidence of PD-associated cell process was conducted. Results: Classically, the damage in the dopaminergic neuronal circuits of SNpc is favored by reactive oxidative/nitrosative stress, leading to Cell death. Interestingly, the therapy for PD has only focused on avoiding the symptom progression but not in finding a complete reversion of the disease. Recent evidence suggests that the renin-angiotensin system imbalance and neuroInflammation are the main keys in the progression of experimental PD. Conclusion: The progression of neurodegeneration in SNpc is due to the complex interaction of multiple processes. In this review, we analyzed the main contribution of four cellular processes and discussed in the perspective of novel experimental approaches.

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APA: Copy

Hernandez-Baltazar, Daniel, Nadella, Rasajna, Zavala Flores, Laura Mireya, Rosas Jarquin, Christian de Jesus, Rovirosa Hernandez, Maria de Jesus, & Villanueva Olivo, Arnulfo. (2019). Four main therapeutic keys for Parkinson’ s disease: A mini review. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(7), 716-721. SID. https://sid.ir/paper/725208/en

Vancouver: Copy

Hernandez-Baltazar Daniel, Nadella Rasajna, Zavala Flores Laura Mireya, Rosas Jarquin Christian de Jesus, Rovirosa Hernandez Maria de Jesus, Villanueva Olivo Arnulfo. Four main therapeutic keys for Parkinson’ s disease: A mini review. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(7):716-721. Available from: https://sid.ir/paper/725208/en

IEEE: Copy

Daniel Hernandez-Baltazar, Rasajna Nadella, Laura Mireya Zavala Flores, Christian de Jesus Rosas Jarquin, Maria de Jesus Rovirosa Hernandez, and Arnulfo Villanueva Olivo, “Four main therapeutic keys for Parkinson’ s disease: A mini review,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 7, pp. 716–721, 2019, [Online]. Available: https://sid.ir/paper/725208/en

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