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Information Journal Paper

Title

Total flavonoid extract from Coreopsis tinctoria Nutt. protects rats against myocardial ischemia/reperfusion injury

Pages

  1016-1023

Abstract

 Objective(s): This study aimed to evaluate the protective effects of total flavonoid extract from Coreopsis tinctoria Nutt. (CTF) against myocardial ischemia/reperfusion injury (MIRI) using an isolated Langendorff rat heart model. Materials and Methods: Left ventricular developed pressure (LVDP) and the maximum rate of rise and fall of LV pressure (± dp/dtmax) were recorded. Cardiac injury was assessed by analyzing lactate dehydrogenase (LDH) and creatine kinase (CK) released in the coronary effluent. Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) levels were determined. Myocardial inflammation was assessed by monitoring tumor necrosis factor-alpha (TNF-α ), C-reactive protein (CRP), interleukin-8 (IL-8), and interleukin-6 (IL-6) levels. Myocardial infarct size was estimated. Cell morphology was assessed by 2, 3, 5-triphenyltetrazolium chloride and hematoxylin and eosin (HE) staining. Cardiomyocyte apoptosis was determined by terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) staining. Results: Pretreatment with CTF significantly increased the heart rate and increased LVDP, as well as SOD and GSH-Px levels. In addition, CTF pretreatment decreased the TUNEL-positive cell ratio, infarct size, and levels of CK, LDH, MDA, TNF-α , CRP, IL-6, and IL-8. Conclusion: These results suggest that CTF exerts Cardio-protective effects against MIRI via Anti-oxidant, Anti-inflammatory, and anti-apoptotic activities.

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    • Cite

    APA: Copy

    Zhang, Ya, Yuan, Changsheng, Fang, He, LI, JIA, Su, Shanshan, & Chen, Wen. (2016). Total flavonoid extract from Coreopsis tinctoria Nutt. protects rats against myocardial ischemia/reperfusion injury. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(9), 1016-1023. SID. https://sid.ir/paper/725238/en

    Vancouver: Copy

    Zhang Ya, Yuan Changsheng, Fang He, LI JIA, Su Shanshan, Chen Wen. Total flavonoid extract from Coreopsis tinctoria Nutt. protects rats against myocardial ischemia/reperfusion injury. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(9):1016-1023. Available from: https://sid.ir/paper/725238/en

    IEEE: Copy

    Ya Zhang, Changsheng Yuan, He Fang, JIA LI, Shanshan Su, and Wen Chen, “Total flavonoid extract from Coreopsis tinctoria Nutt. protects rats against myocardial ischemia/reperfusion injury,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 9, pp. 1016–1023, 2016, [Online]. Available: https://sid.ir/paper/725238/en

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