مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

The role of exosomes contents on genetic and epigenetic alterations of recipient cancer cells

Pages

  1031-1039

Abstract

 Exosomes, as a mediator of cell-to-cell transfer of genetic information, act an important role in intercommunication between tumor cells and their niche including fibroblasts, endothelial cells, adipocytes and monocytes. Several studies have shown that tumor cells can influence their neighboring cells by releasing exosomes. These exosomes provide signaling cues for stimulation, activation, proliferation and differentiation of cells. Exosomes contain mRNAs, microRNAs (miRNA), and proteins that could be transferred to target cells inducing genetic and epigenetic changes. By facilitating the horizontal transfer of bioactive molecules such as proteins, RNAs and microRNAs, they are now thought to have vital roles in tumor invasion and metastases, inflammation, coagulation, and stem cell renewal and expansion. The aim of this review article is to discuss the significance of exosome-mediated intercellular communication within the tumor biology.

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    • Cite

    APA: Copy

    Dehbashi Behbahani, Golnoush, KHANI, SOGHRA, MAHMOODZADEH HOSSEINI, HAMIDEH, Abbaszadeh Goudarzi, Kazem, & Nazeri, Saeed. (2016). The role of exosomes contents on genetic and epigenetic alterations of recipient cancer cells. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(10), 1031-1039. SID. https://sid.ir/paper/725240/en

    Vancouver: Copy

    Dehbashi Behbahani Golnoush, KHANI SOGHRA, MAHMOODZADEH HOSSEINI HAMIDEH, Abbaszadeh Goudarzi Kazem, Nazeri Saeed. The role of exosomes contents on genetic and epigenetic alterations of recipient cancer cells. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(10):1031-1039. Available from: https://sid.ir/paper/725240/en

    IEEE: Copy

    Golnoush Dehbashi Behbahani, SOGHRA KHANI, HAMIDEH MAHMOODZADEH HOSSEINI, Kazem Abbaszadeh Goudarzi, and Saeed Nazeri, “The role of exosomes contents on genetic and epigenetic alterations of recipient cancer cells,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 10, pp. 1031–1039, 2016, [Online]. Available: https://sid.ir/paper/725240/en

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