Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

224
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

130
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

Linc-ROR and its spliced variants 2 and 4 are significantly up-regulated in esophageal squamous cell carcinoma

Pages

  1131-1135

Abstract

 Objective(s): Similar characteristics of molecular pathways between cellular reprogramming events and tumorigenesis have been accentuated in recent years. Reprogramming-related transcription factors, also known as Yamanaka factors (OCT4, SOX2, KLF4, and c-MYC), are also well-known oncogenes promoting cancer initiation, progression, and cellular transformation into cancer stem cells. Long Non-coding RNAs (lncRNAs) are a major class of RNA molecules with emerging roles in stem cell pluripotency, cellular reprogramming, cellular transformation, and tumorigenesis. The long intergenic Non-coding RNA ROR (lincRNA-ROR, Linc-ROR) acts as a regulator of cellular reprograming through sponging miR-145 that normally negatively regulates the expression of the stemness factors NANOG, OCT4, and SOX2. Materials and Methods: Here, we employed a real-time PCR approach to determine the expression patterns of Linc-ROR and its two novel Spliced variants (variants 2 and 4) in esophageal squamous cell carcinoma (ESCC). Results: The quantitative real-time RT-PCR results revealed a significant up-regulation of Linc-ROR (P=0. 0098) and its variants 2 (P=0. 0250) and 4 (P=0. 0002) in tumor samples of ESCC, compared to their matched non-tumor tissues obtained from the margin of same tumors. Our data also demonstrated a significant up-regulation of variant 4 in high-grade tumor samples, in comparison to the low-grade ones (P=0. 04). Moreover, the ROC curve analysis demonstrated that the variant 4 of ROR has a potential to discriminate between tumor and non-tumor samples (AUC=0. 66, P<0. 05). Conclusion: Our data suggest a significant up-regulation of Linc-ROR and its variants 2 and 4 in ESCC tissue samples.

Cites

References

  • No record.

    • Cite

    APA: Copy

    Sahebi, Reza, MALAKOOTIAN, MAHSHID, Balalaee, Baharak, Shahryari, Alireza, KHOSHNIA, MASOUD, ABBASZADEGAN, MOHAMMAD REZA, MORADI, ABDOLVAHAB, & MOWLA, SEYED JAVAD. (2016). Linc-ROR and its spliced variants 2 and 4 are significantly up-regulated in esophageal squamous cell carcinoma. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(10), 1131-1135. SID. https://sid.ir/paper/725370/en

    Vancouver: Copy

    Sahebi Reza, MALAKOOTIAN MAHSHID, Balalaee Baharak, Shahryari Alireza, KHOSHNIA MASOUD, ABBASZADEGAN MOHAMMAD REZA, MORADI ABDOLVAHAB, MOWLA SEYED JAVAD. Linc-ROR and its spliced variants 2 and 4 are significantly up-regulated in esophageal squamous cell carcinoma. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(10):1131-1135. Available from: https://sid.ir/paper/725370/en

    IEEE: Copy

    Reza Sahebi, MAHSHID MALAKOOTIAN, Baharak Balalaee, Alireza Shahryari, MASOUD KHOSHNIA, MOHAMMAD REZA ABBASZADEGAN, ABDOLVAHAB MORADI, and SEYED JAVAD MOWLA, “Linc-ROR and its spliced variants 2 and 4 are significantly up-regulated in esophageal squamous cell carcinoma,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 10, pp. 1131–1135, 2016, [Online]. Available: https://sid.ir/paper/725370/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top