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Information Journal Paper

Title

Can Amlodipine Improve the Pre-ovulatory Follicle Blood Flow in Women with Polycystic Ovarian Syndrome?

Pages

  59-94

Abstract

 Background: A reduction in intra-ovarian vascular resistance is necessary to achieve pregnancy in a natural cycle. The aim of this RCT was to detect whether a vasodila-tor calcium channel blocker, Amlodipine, could increase the pre-ovulatory follicular blood flow, enhance follicular maturation in women with PCOS and improve ovula-tory outcome. Methods: Sixty women received induction by Clomiphene Citrate (CC); thirty were given Amlodipine (Amlodipine group) and the other 30 women were given placebo (Placebo group). The pattern of Pre-ovulatory follicle blood flow was studied by col-or and power Doppler ultrasonography pre and post drug administration. Independ-ent t-test was used to compare mean values of the 2 groups. The p<0. 05 is consid-ered statistically significant. Results: When comparing the Doppler effect of Amlodipine versus placebo in the treatment cycle, it was found that mean value of ovarian arteries (OA) pulsatility in-dex was lower in Amlodipine group but it didn't reach statistical significance (p= 0. 063); however, the mean value of OA resistance index reached statistical signifi-cance (p=0. 028) in Amlodipine group. Moreover, in the second cycle, endometrial thickness was significantly higher (p=0. 006) in women of the Amlodipine group when compared to those of the placebo group. At least one sonographically detecta-ble mature follicle (≥ 18 mm) was observed in 54. 5% (36/66) during the first cycle. At the second cycle, this proportion significantly rose to 86. 7% (26/30) in the am-lodipine group, but marginally and non-significantly to 56. 7% (17/30) in the placebo group. Conclusion: Amlodipine as calcium channel blocker was proved to have a role in improving ovarian blood flow at the time of ovulation and enhancing follicular mat-uration and thus, it may increase the chances of conception.

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    APA: Copy

    El Faham, Doaa, Ali, Khaled, Salah El Din, Adel, Bibars, Mamdouh, & Azmy, Osama. (2019). Can Amlodipine Improve the Pre-ovulatory Follicle Blood Flow in Women with Polycystic Ovarian Syndrome?. JOURNAL OF REPRODUCTION AND INFERTILITY, 20(2), 59-94. SID. https://sid.ir/paper/725377/en

    Vancouver: Copy

    El Faham Doaa, Ali Khaled, Salah El Din Adel, Bibars Mamdouh, Azmy Osama. Can Amlodipine Improve the Pre-ovulatory Follicle Blood Flow in Women with Polycystic Ovarian Syndrome?. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2019;20(2):59-94. Available from: https://sid.ir/paper/725377/en

    IEEE: Copy

    Doaa El Faham, Khaled Ali, Adel Salah El Din, Mamdouh Bibars, and Osama Azmy, “Can Amlodipine Improve the Pre-ovulatory Follicle Blood Flow in Women with Polycystic Ovarian Syndrome?,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 20, no. 2, pp. 59–94, 2019, [Online]. Available: https://sid.ir/paper/725377/en

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