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Information Journal Paper

Title

A new insight into viral proteins as Immunomodulatory therapeutic agents. KSHV vOX2 a homolog of human CD200 as a potent anti-inflammatory protein

Pages

  2-13

Abstract

 The physiologic function of the immune system is defence against infectious microbes and tumour cells, Therefore, need to have precise modulatory mechanisms to maintain the body homeostasis. The mammalian cellular CD200 (OX2)/CD200R interaction is one of such modulatory mechanisms in which myeloid and lymphoid cells are regulated. CD200 and CD200R molecules are membrane proteins that their immunomodulatory effects are able to suppress inflammatory responses, particularly in the privilege sites such as CNS and eyes. Kaposi’ s sarcoma-associated herpesvirus (KSHV), encodes a wide variety of immunoregulatory proteins which play central roles in modulating inflammatory and anti-inflammatory responses in favour of virus dissemination. One such protein is a homologue of the human CD200, encoded by open reading frame (ORF) K14 and therefore called vOX2/vCD200. Based on gene expression profile during the KSHV life cycle, it is hypothesised that vOX2 modulates host inflammatory responses. Moreover, it seems that vOX2 involves in cell adhesion and modulates innate immunity and promotes Th2 immune responses. In this review the activities of mammalian CD200 and KSHV CD200 in cell adhesion and immune system modulation are reviewed as potential therapeutic agents.

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    APA: Copy

    MOUSAVINEZHAD MOGHADDAM, MARYAM, Amin, Abbas Ali, RAFATPANAH, HOUSHANG, & REZAEE, SEYED ABDOL RAHIM. (2016). A new insight into viral proteins as Immunomodulatory therapeutic agents. KSHV vOX2 a homolog of human CD200 as a potent anti-inflammatory protein. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(1), 2-13. SID. https://sid.ir/paper/725707/en

    Vancouver: Copy

    MOUSAVINEZHAD MOGHADDAM MARYAM, Amin Abbas Ali, RAFATPANAH HOUSHANG, REZAEE SEYED ABDOL RAHIM. A new insight into viral proteins as Immunomodulatory therapeutic agents. KSHV vOX2 a homolog of human CD200 as a potent anti-inflammatory protein. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(1):2-13. Available from: https://sid.ir/paper/725707/en

    IEEE: Copy

    MARYAM MOUSAVINEZHAD MOGHADDAM, Abbas Ali Amin, HOUSHANG RAFATPANAH, and SEYED ABDOL RAHIM REZAEE, “A new insight into viral proteins as Immunomodulatory therapeutic agents. KSHV vOX2 a homolog of human CD200 as a potent anti-inflammatory protein,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 1, pp. 2–13, 2016, [Online]. Available: https://sid.ir/paper/725707/en

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